Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3. Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects4.
1) Lyss et al. (1998), The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65; J. Biol. Chem., 273 33508
2) Lyss et al. (1997), Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB; Biol. Chem., 278 951
3) Berges et al. (2009), Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms; Mol. Immunol., 46 2892
4) Huang et al. (2005), Potent inhibition of human telomerase by helenalin; Cancer Lett., 227 169