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Product Details

Helenalin | NFkB inhibitor

Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3. Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects4.

References/Citations
1) Lyss et al. (1998), The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65; J. Biol. Chem., 273 33508
2) Lyss et al. (1997), Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB; Biol. Chem., 278 951
3) Berges et al. (2009), Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms; Mol. Immunol., 46 2892
4) Huang et al. (2005), Potent inhibition of human telomerase by helenalin; Cancer Lett., 227 169

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Catalog#  10-2783

$238.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
6754-13-8
Catalog Number:
10-2783
Activity:
NFκB inhibitor
Chemical Name:
Natural sesquiterpenoid from Arnica species
Molecular Weight:
262.31
Molecular Formula:
C15H18O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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