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Product Details

Herboxidiene | Spliceosome inhibitor

Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2 Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3 Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4 Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5

References/Citations

1) Miller-Wideman et al. (1992), Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physio-chemical and biological properties; J. Antibiot. (Tokyo), 45 914
2) Gao et al. (2013), Comparison of splicing factor 3b inhibitors in human cells; Chembiochem, 14 49
3) Hasegawa et al. (2011), Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product; ACS Chem. Biol., 6 229
4) Jung et al. (2015), Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α; Arch. Pharm. Res., 38 1728
5) Martinez-Montiel et al. (2016), Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment; Biomed. Res. Int., epub ahead of print

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Herboxidiene | 142861-00-5 | Structure | Supplier

Catalog#  10-1614-0200

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
142861-00-5
Catalog Number:
10-1614
Activity:
Spliceosome inhibitor
Alternate Names:
GEX1A
Molecular Weight:
438.60
Molecular Formula:
C25H42O6
Solubility:
Soluble in DMSO or Ethanol
Physical Properties:
White solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Potent and selective inhibitor of spliceosome subunit SF3b. Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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