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immunosuppressants

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  • 6-Thioguanine | Anticancer agent / Downregulates DNMT1
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • A77 1726 | 108605-62-5 | Structure | supplier
    $45.00
    A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide (Cat.# 10-2369) is rapidly metabolized in human hepatocytes to...

  • Ascomycin | FKBP ligand immunosuppressant
    $35.00
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

  • Caerulomycin A | Blocks STAT1 signaling / Immunosuppressant
    $80.00
    Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion in vitro and in vivo1. Caerulomycin A induces expansion of regulatory T cells by via...

  • Cyclosporin A | 59865-13-3 | Structure | Supplier
    $50.00
    Cyclosporin A (59865-16-6) is an immunosupressant. The CsA-cyclophilin complex binds to and inhibits calcineurin, a type 2B phosphatase. Cell permeable. References/Citations1) Liu et al. (1993), FK506 and cyclosporin:...

  • Everolimus | mTOR inhibitor
    $70.00
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • FK-506 | 104987-11-3 | Structure | Supplier
    $100.00
    FK-506 (104987-11-3) induces immunosuppression by inhibiting T cell proliferation. Inhibits FKBP12 and calcineurin (IC50 ~ 1 nM). Cell permeable. References/Citations1) Yu et al. (2006), Effects of cyclosporine A, FK506 and...

  • Helenalin | NFkB inhibitor
    $238.00
    Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3...

  • Kynurenine (L) | Endogenous Ahr agonist
    $38.00
    Kynurenine (2922-83-0) is a tryptophan catabolite1. Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading...

  • Leflunomide | Immunosuppressant
    $40.00
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

  • Mycophenolate mofetil | Immunomodulator
    $35.00
    Mycophenolate mofetil (128794-94-5) is a mycophenolic acid prodrug. Immunosuppressive agent useful in prevention of organ allograft rejection1. Mycophenolate mofetil is metabolized to mycophenolic acid (Cat.# 10-2087) in...

  • Mycophenolic acid | Immunosuppressant
    $70.00
    Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5'-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory...

  • Myriocin | Blocks sphingolipid biosynthesis
    $65.00
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • Palmitoylethanolamine | 544-31-0 | Structure | Supplier
    $60.00
    Palmitoylethanolamide (544-31-0) is an endogenous cannabinoid. Weak ligand for CB1 (Ki= 23.8 μM) and CB2 (Ki = 13.9 μM) receptors. Inhibits fatty acid amide hydrolase (FAAH) ((IC50 = 5.1 μM). Modulates mast cell...

  • Rapamycin | 53123-88-9 | Structure | Supplier
    $100.00
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Rocaglamide | TNFalpha inhibitor
    $60.00
    Rocaglamide (84573-16-0) is a potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200nM.1  It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and...

  • THI | Immunomodulator
    $95.00
    THI (94944-70-4) was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering...

  • Tofacitinib | JAK inhibitor
    $95.00
    Tofacitinib (477600-75-2) is a JAK3 inhibitor, currently in clinical use. References/Citations1) Beavo et al. (1970), Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase...

  • Triptolide | Immunosuppressant
    $35.00
    Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.  Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1...

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