my account
Login
  Loading... Please wait...

Product Details

Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor

Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells2. Possesses antiangiogenic activity3. Indirubin-3'-monoxime attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer's disease4. Cell permeable.

References/Citations
1) Leclerc et al. (2001), Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem., 276 251
2) Damiens et al. (2001), Anti-mitotic properties of indirubin-3'-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene, 20 3786
3) Kim et al. (2011), Indirubin-3'-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem., 112 1384
4) Ding et al. (2010), Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease; Neurobiol. Dis., 39 156

swipe
Indirubin-3'-monoxime | 160807-49-8 | Structure | Supplier

Catalog#  10-1488

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
160807-49-8
Catalog Number:
10-1488
Activity:
GSK-3β and CDK inhibitor
Alternate Names:
Indirubin-3'oxime
Chemical Name:
3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Molecular Weight:
277.29
Molecular Formula:
C16H11N3O2
Solubility:
Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
Dark red or brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor to your wish list.