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PhysioProcesses

Inflammation

Acute inflammation is an immune response to a pathogen, irritant, or injury to remove whatever has caused the response, dispose of damaged tissue, and initiate healing. Resident immune cells at the site of insult recognize pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS) and release various inflammatory mediators. Initial responses include vasodilation, increased vascular permeability, and extravasation of leukocytes. Mediators of inflammation include bradykinins, the complement system, cytokines, chemokines, leukotrienes, and prostaglandins among others. Chronic inflammation is characterized by infiltration of the tissue site by macrophages and lymphocytes leading to overall tissue damage. Chronic inflammatory diseases include diabetes, cardiovascular diseases, arthritis, allergies, cancer, and chronic obstructive pulmonary disease.

COX

SC-560 | Selective COX-1 inhibitor

CAS:
18817-13-2
Catalog Number:
10-2531
Activity:
Selective COX-1 inhibitor
Chemical Name:
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Molecular Weight:
352.74
Molecular Formula:
C17H12ClF3N2O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Brown solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Rofecoxib | Selective COX-2 inhibitor

CAS:
162011-90-7
Catalog Number:
10-2440
Activity:
Selective COX-2 inhibitor
Alternate Names:
MK-966
Chemical Name:
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Molecular Weight:
314.36
Molecular Formula:
C17H14O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Sulindac Sulfide | NFkappaB inhibitor

CAS:
32004-67-4
Catalog Number:
10-2156
Activity:
NFkappaB inhibitor
Chemical Name:
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
Molecular Weight:
340.42
Molecular Formula:
C20H17FO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cytokines

CDDO-Me | Nrf2 activator

CAS:
218600-53-4
Catalog Number:
10-5449
Activity:
Nrf2 activator
Chemical Names:
2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
Alternate Name:
Bardoxolone methyl; NSC-713200; RTA 402; TP-155
Molecular Weight:
505.70
Molecular Formula:
C32H43NO4
Solubility:
Soluble in DMSO (25 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GSK4112 | Rev-Erbα agonist

CAS:
1216744-19-2
Catalog Number:
10-5493
Activity:
Rev-Erbα agonist
Chemical Names:
N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester
Alternate Name:
SR6452
Molecular Weight:
396.89
Molecular Formula:
C18H21ClN2O4S
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

(5Z)-7-Oxozeaenol | TAK1 inhibitor

CAS:
253863-19-3
Catalog Number:
10-3023
Activity:
TAK1 inhibitor
Chemical Names:
(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Alternate Name:
LL-Z-1640-2
Molecular Weight:
362.38
Molecular Formula:
C19H22O7
Solubility:
Soluble in DMSO (9 mg/ml); ethanol (3 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Glucocorticoid receptors

Dexamethasone | Apoptosis inducing glucocorticoid

CAS:
50-02-2
Catalog Number:
10-1134
Activity:
Apoptosis inducing glucocorticoid
Chemical Name:
(11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Molecular Weight:
392.46
Molecular Formula:
C22H29FO5
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
RT

Inflammasome

Leukotriene receptor

Gliotoxin | Immunomodulator

CAS:
67-99-2
Catalog Number:
10-2076
Activity:
Immunomodulator
Chemical Names:

(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
[1,2-a]indole-1,4-dione; Aspergillin

Molecular Weight:
326.39
Molecular Formula:
C13H14N2O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White lyophilized solid
Purity:
98%  HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist

CAS:
103177-37-3
Catalog Number:
10-2441
Activity:
Leukotriene CysLT1 antagonist / GRP17 antagonist
Chemical Name:
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
Alternate Names:
ONO-1078
Molecular Weight:
481.51
Molecular Formula:
C27H23N5O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Montelukast sodium | Leukotriene antagonist and GPR17 antagonist

CAS:
151767-02-1
Catalog Number:
10-2597
Activity:
Leukotriene antagonist and GRP17 antagonist
Chemical Name:
2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt
Alternate Names:
MK-0476
Molecular Weight:
608.17
Molecular Formula:
C35H35ClNO3S
Solubility:
Soluble in DMSO (up to 60 mg/ml), in Water (up to 30 mg/ml) , or in Ethanol (up to 60 mg/ml)
Physical Properties:
Solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Lipoxygenase

Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells

CAS:
491-67-8
Catalog Number:
10-2773
Activity:
Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
Chemical Name:
5,6,7-Trihydroxyflavone
Molecular Weight:
270.24
Molecular Formula:
C15H10O5
Physical Properties:
Yellow or yellow-green solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT

EPA free acid | omega-3 fatty acid

CAS:
10417-94-4
Catalog Number:
10-1313
Activity:
omega-3 fatty acid
Alternate Names:
Eicosapentaenoic acid
Chemical Name:
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic acid (20:5, n-3)
Molecular Weight:
302.46
Molecular Formula:
C20H30O2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
Colorless to pale yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied (unopened). After opening, EPA must be stored under inert gas at -80°C. Solutions in DMSO or ethanol should also be stored under inert gas and may be kept at -80°C for up to 2 months.
Shipping Code:
RT

MK-886 | FLAP inhibitor

CAS:
118414-82-7
Catalog Number:
10-1040
Activity:
FLAP inhibitor
Alternate Names:
L-663,536
Chemical Name:
3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
Molecular Weight:
472.08
Molecular Formula:
C27H34ClNO2S
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

NF-κB

PD 123319 ditrifluoroacetate | Angiotensin II type II antagonist

CAS:
136676-91-0
Catalog Number:
10-4959
Activity:
Angiotensin II AT2 antagonist
Chemical Names:
(6S)-1-[[4-(Dimethylamino)-3-methylphenylmethyl]-5-(2,2diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Molecular Weight:
736.66
Molecular Formula:
C31H32N4O3·2CF3CO2H
Solubility:
Soluble in DMSO (>25 mg/ml); Water (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

NMDA receptors

Memantine HCl | NMDA antagonist / Anti-Alzheimer’s

CAS:
41100-52-1
Catalog Number:
10-2346
Activity:
NMDA antagonist / Anti-Alzheimer’s
Chemical Name:
3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl
Alternate Names:
3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl
Molecular Weight:
215.76
Molecular Formula:
C12H21N • HCl
Solubility:
Soluble in Water (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

MDL29,951 | GPR17 activator

CAS:
130798-51-5
Catalog Number:
10-4537
Activity:
GPR17 activator
Chemical Name:
3-(2-Carboxy-4,6-dichloroindol-3-yl)propionic acid
Molecular Weight:
302.11
Molecular Formula:
C12H9Cl2NO4
Solubility:
Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR: (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

KB-R7943 mesylate | NCX inhibitor

CAS:
182004-65-5
Catalog Number:
10-1163
Activity:
TRPC channel blocker
Chemical Name:
2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate
Molecular Weight:
427.49
Molecular Formula:
C16H17N3O3S CH3SO3H
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PAF

WEB-2086 | PAF receptor antagonist

CAS:
105219-56-5
Catalog Number:
10-1389
Activity:
PAF receptor antagonist
Alternate Names:
Apafant
Chemical Name:
4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
Molecular Weight:
455.96
Molecular Formula:
C22H22ClN5O2S
Solubility:
Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Ginkgolide B | PAF receptor antagonist

CAS:
15291-77-7
Catalog Number:
10-1080
Activity:
PAF antagonist
Alternate Names:
BN 52021
Chemical Name:
Natural product isolated from Ginko biloba
Molecular Weight:
424.41
Molecular Formula:
C20H24O10
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT

Pattern recognition receptors

Loxoribine | TLR7 agonist

CAS:
121288-39-9
Catalog Number:
10-3780
Activity:
TLR7 agonist
Chemical Name:
7-Allyl-7,8-dihydro-8-oxoguanosine
Alternate Name:
RWJ-21757
Molecular Weight:
339.30
Molecular Formula:
C13H17N5O6
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
96% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Allopregnanolone | GABA-A positive allosteric modulator

CAS:
516-54-1
Catalog Number:
10-3489
Activity:
GABA-A positive allosteric modulator
Chemical Name:
(3α,5α)-3-Hydroxy-pregnan-20-one
Alternate Name:
(3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
Molecular Weight:
318.49
Molecular Formula:
C21H34O2
Solubility:
Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Imiquimod | TLR7 Agonist

CAS:
99011-02-6
Catalog Number:
10-4230
Alternate Name:
R837
Activity:
TLR7 agonist
Chemical Name:
1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine
Molecular Weight:
240.30
Molecular Formula:
C14H16N4
Solubility:
Soluble in DMSO (2 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Prostanoid receptors & prostaglandins

Grapiprant | EP4 Receptor antagonist

CAS:
415903-37-6
Catalog Number:
10-4006
Activity:
EP4 Receptor antagonist
Chemical Name:
1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
Alternate Names:
CJ-023423; ARY-007
Molecular Weight:
491.61
Molecular Formula:
C26H29N5O3S
Solubility:
Soluble in DMSO (up to at least 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

TG 4-155 | EP2 receptor antagonist

CAS:
1164462-05-8
Catalog Number:
10-1574
Activity:
EP2 receptor antagonist
Chemical Name:
(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Molecular Weight:
394.47
Molecular Formula:
C23H26N2O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Zileuton | 5-LO inhibitor

CAS:
111406-87-2
Catalog Number:
10-1098
Activity:
5-LO inhibitor
Chemical Name:
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Molecular Weight:
236.29
Molecular Formula:
C11H12N2O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
>98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

ROS

Auraptene | Neuroprotective / Neuritogenic agent

CAS:
495-02-3
Catalog Number:
10-2593
Activity:
Neuroprotective / Neuritogenic agent
Chemical Name:
7-[[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one
Alternate Name:
7-Geranyloxycoumarin
Molecular Weight:
298.36
Molecular Formula:
C19H22O3
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Bakuchiol | Antioxidant

CAS:
10309-37-2
Catalog Number:
10-3161
Activity:
Antioxidant
Chemical Name:
(S)-Bakuchiol, 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol
Molecular Weight:
258.42
Molecular Formula:
C17H22O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Colorless oil
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Pirfenidone | Antifibrotic

CAS:
53179-13-8
Catalog Number:
10-2307
Activity:
Antifibrotic
Chemical Name:
5-Methyl-1-phenyl-2(1H)-pyridinone
Molecular Weight:
185.23
Molecular Formula:
C12H11NO
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

STING

RU.521 | cGAS Inhibitor

CAS:
2262452-06-0
Catalog Number:
10-4140
Activity:
cGAS Inhibitor
Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:
415.23
Molecular Formula:
C19H12Cl2N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

2′,3′-cGAMP | Endogenous STING agonist

CAS:
1441190-66-4
Catalog Number:
10-1639
Activity:
Endogenous STING agonist
Chemical Name:
Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
Alternate Name:
2′,3’cyclic GMP-AMP
Molecular Weight:
718.38
Molecular Formula:
C20H22N10O13P2·2Na
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DMXAA | STING agonist

CAS:
117570-53-3
Catalog Number:
10-2676
Activity:
STING agonist
Chemical Name:
5,6-Dimethylxanthenone-4-acetic acid
Alternate Names:
ASA404; Vadimezan
Molecular Weight:
282.29
Molecular Formula:
C17H14O4
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in DMF (up to 14 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Other Inflammation

Gue1654 | OXE-R biased antagonist

Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not

SR3335 | RORα partial inverse agonist

SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at RORß, RORγ, or FXR.1 It was able to suppress gluconeogenesis

GSK620 | BD2 selective BET inhibitor

GSK620 (2088410-46-0) is a BET inhibitor 220-fold more selective for BD2 over BD1 (pIC50 BD2 = 7.1; BD1 = 4.8).1 It ameliorated collagen-induced arthritis in a rat model