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  • 2GBI | Hv1 channel blocker
    2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3  Inhibition of Hv1 is...

  • Alamethicin | Pore-forming antimicrobial peptide
    Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and...

  • Nigericin Na | Induces rapid intracellular acidification
    Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin...

  • Nonactin | Monovalent cation ionophore K+ and NH4+
    Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ 1. Upregulates levels of mitochondrial stress proteins HSP58 and GRP752. Nonactin abolishes mitochondrial membrane potential3...

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