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Potassium

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  • 1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    $40.00
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

  • Cereulide | Mitochondrial toxin
    $264.00
    An emetic toxin produced by Bacillus cereus. Acts as an ionophore with high selectivity for K+. Stimulates swelling and respiration in rat liver mitochondria.1  It is a lipophilic cyclopeptide and is rapidly absorbed in...

  • Diazoxide | K-ATP channel activator
    $40.00
    Activates ATP-dependent K+ channels1 via inducing translocation of PKC-epsilon from the cytosol to the mitochondria2. Hyperglycemic agent. Induces powerful protective effects against cardiac ischemia via multiple mechanisms...

  • Dofetilide | 115256-11-6 | Structure | Suplier
    $65.00
    Dofetilide (115256-11-6) is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel...

  • E-4031 | 113558-89-7 | Structure | Supplier
    $98.00
    E-4031 (113558-89-7) is a selective hERG potassium channel blocker. Inhibits the rapid delayed-rectifier K+ current (IKr). Class III antiarrhythmic agent. Cell permeable. References/Citations1) Ficker et al. (2002), The...

  • GBR-12909 2HCl | Dopamine reuptake inhibitor
    $60.00
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • Glyburide | 10238-21-8 | Structure | Supplier
    $30.00
    Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin...

  • ICA-11381 | 325457-99-6 | Structure | Supplier
    $55.00
    ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM)1. KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity in...

  • Minoxidil | 38304-91-5 | Structure | Supplier
    $56.00
    Minoxidil (38304-91-5) is a direct antihypertensive peripheral vasodilator acting via activation of KATP channels leading to relaxation of smooth muscle.1 Active metabolite is minoxidil sulfate (IC50 = 0.14 μM). Minoxidil...

  • ML-297 | 1443246-62-5 | Structure | Supplier
    $70.00
    ML-297 (1443246-62-5) is a selective GIRK 1/2 (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2...

  • Nigericin Na | Induces rapid intracellular acidification
    $50.00
    Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin...

  • Nonactin | Monovalent cation ionophore K+ and NH4+
    $40.00
    Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ 1. Upregulates levels of mitochondrial stress proteins HSP58 and GRP752. Nonactin abolishes mitochondrial membrane potential3...

  • Penitrem A | High conductance calcium activated potassium channel inhibitor
    $50.00
    Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ (BK, KCa1.1) channel (100% block at 10 nM).1 Displays brain neurotoxicity...

  • Salinomycin Na | Cancer stem cell inhibitor
    $48.00
    Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma1...

  • SKF-96365 |130495-35-1 | Structure | Supplier
    $65.00
    SKF-96365 (130495-35-1) is an inhibitor of receptor-mediated calcium entry (RMCE) with IC50's of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca2+ but...

  • SKF525A HCl | Cytochrome P450 inhibitor
    $50.00
    SKF-525A (62-68-0) is a commonly used non-selective Cytochrome P450 inhibitor.1  It is also a local anesthetic2 acting via blockage of the acetylcholine receptor3 – it is a commonly used reagent to stabilize the...

  • Valinomycin | Induces loss of mitochondrial membrane potential
    $42.00
    Valinomycin (2001-95-8) is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 Valinomycin can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via...

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