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BiochemicalTargets

Kinases

The phosphorylation state of a biologically relevant molecule affects its activity, reactivity, and ability to interact with other molecules. The enzymes responsible for adding phosphate groups, kinases, act on many types of molecules including proteins, lipids, carbohydrates, and nucleotides. These kinases mediate multiple signal transduction pathways and are responsible for modulating many essential cellular functions including metabolism, proliferation, differentiation, and survival. Dysfunction of kinases is involved in many pathological states including cancer, neurodegeneration, inflammation, metabolic and developmental disorders, and autoimmune diseases.

ALK

Brigatinib | pan-ALK inhibitor

CAS:
1197953-54-0
Catalog Number:
10-5034
Activity:
pan-ALK inhibitor
Chemical Names:
5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4- pyrimidinediamine
Alternate Name:
AP26113
Molecular Weight:
584.02
Molecular Formula:
C29H39ClN7O2P
Solubility:
Soluble in DMSO (1 mg/ml with warming)
Physical Properties:
White to off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

GW788388 | TGF-ß receptor kinase inhibitor

CAS:
452342-67-5
Catalog Number:
10-5521
Activity:
TGF-ß receptor kinase inhibitor
Chemical Names:
4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
Molecular Weight:
425.49
Molecular Formula:
C25H23N5O2
Solubility:
Soluble in DMSO (18 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Alectinib | Potent and selective ALK inhibitor

CAS:
1256580-46-7
Catalog Number:
10-4793
Activity:
Potent and selective ALK inhibitor
Chemical Name:
9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
Alternate Name:
CH5424802
Molecular Weight:
482.62
Molecular Formula:
C30H34N4O2
Solubility:
Soluble in DMSO (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.
Shipping Code:
RT

Cell cycle/cell division

LDN-192960 2HCl | Haspin and DYRK2/3 inhibitor

CAS:
184582-62-5
Catalog Number:
10-4836
Activity:
Haspin and DYRJ2/3 inhibitor
Chemical Names:
3-(2,7-Dimethoxyacridin-9-yl)sulfanylpropan-1-amine dihydrochloride
Molecular Weight:
401.35
Molecular Formula:
C18H20N2O2S·2HCl
Solubility:
Soluble in DMSO (>25 mg/ml); Water (2 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

SU9516 | pan-specific CDK inhibitor

CAS:
SU9516
Catalog Number:
10-5705
Activity:
pan-specific CDK inhibitor
Chemical Names:
(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one
Molecular Weight:
241.25
Molecular Formula:
C13H11N3O2
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Orange solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Adavosertib | Wee1 kinase inhibitor

CAS:
955365-80-7
Catalog Number:
10-4823
Activity:
Wee1 kinase inhibitor
Chemical Names:
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
Alternate Name:
MK-1775; AZD1775
Molecular Weight:
500.61
Molecular Formula:
C27H32N8O2
Solubility:
Soluble in DMSO (70 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DNA damage response

VE-821 | Potent and selective ATR inhibitor

CAS:
1232410-49-9
Catalog Number:
10-5589
Activity:
ATR inhibitor
Chemical Names:
3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
Molecular Weight:
368.41
Molecular Formula:
C18H16N4O3S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

AZ20 | ATR kinase inhibitor

CAS:
1233339-22-4
Catalog Number:
10-4675
Activity:
ATR kinase inhibitor
Chemical Name:
4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole
Molecular Weight:
412.51
Molecular Formula:
C21H24N4O3S
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

NU7441 | DNA-PK inhibitor

CAS:
503468-95-9
Catalog Number:
10-4810
Activity:
DNA-PK inhibitor
Chemical Name:
8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
Alternate Name:
Ku-57788
Molecular Weight:
413.49
Molecular Formula:
C25H19NO3S
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming).
Physical Properties:
Off-white to beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

ERK

AZD6244 | ERK inhibitor

CAS:
606143-52-6
Catalog Number:
10-4509
Activity:
ERK inhibitor
Alternate Names:
ARRY-142886, Selumetinib
Molecular Weight:
457.68
Molecular Formula:
C17H15BrClFN4O3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

PD 325901 MEK inhibitor

CAS:
391210-10-9
Catalog Number:
10-2161
Activity:
MEK inhibitor
Chemical Name:
N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Molecular Weight:
482.2
Molecular Formula:
C16H14F3IN2O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

PD-98059 | MEK inhibitor

CAS:
167869-21-8
Catalog Number:
10-2159
Activity:
MEK inhibitor
Alternate Names:
2′-Amino-3′-methoxyflavone
Chemical Name:
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Molecular Weight:
267.29
Molecular Formula:
C16H13NO3
Solubility:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Growth factor

GSK-3β

Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor

CAS:
142273-20-9
Catalog Number:
10-3028
Activity:
GSK-3ß/CDK/KLF4 inhibitor
Chemical Names:
9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704
Molecular Weight:
327.18
Molecular Formula:
C16H11BrN2O
Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

IM-12 | GSK-3ß inhibitor

CAS:
1129669-05-1
Catalog Number:
10-5125
Activity:
GSK-3ß inhibitor
Chemical Names:
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Weight:
377.41
Molecular Formula:
C22H20FN3O2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

SB-216763 | GSK-3 inhibitor

CAS:
280744-09-4
Catalog Number:
10-2338
Activity:
GSK-3 inhibitor
Chemical Name:
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Weight:
371.23
Molecular Formula:
C19H12Cl2N2O2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Highly selective inhibitors

JNK-IN-8 | Covalent JNK inhibitor

JNK-IN-8 (1410880-22-6) is a  potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1  JNK blockade with JNK-IN-8 overcomes

LDC1267 | Inhibitor of TAM kinases

LDC1267 (1361030-48-9) is a potent and selective inhibitor of the TAM kinases Tyro3, Axl, and Mer (IC50s respectively: 8 nM, <5 nM, 29 nM).1 It was

Immunoregulatory

LDC1267 | Inhibitor of TAM kinases

LDC1267 (1361030-48-9) is a potent and selective inhibitor of the TAM kinases Tyro3, Axl, and Mer (IC50s respectively: 8 nM, <5 nM, 29 nM).1 It was

JAK

Filgotinib | JAK1 inhibitor

CAS:
1206161-97-8
Catalog Number:
10-5145
Activity:
JAK1 inhibitor
Chemical Names:
N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-ɑ]pyridin-2-yl]-cyclopropanecarboxamide
GLPG0634; GS-6034
Molecular Weight:
425.50
Molecular Formula:
C21H23N5O3S
Solubility:
Soluble in DMSO (15 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Pyridone 6 | pan-JAK inhibitor

CAS:
457081-03-7
Catalog Number:
10-5555
Activity:
pan-JAK inhibitor
Chemical Names:
2-(tert-Butyl)-9-fluoro-1Hbenzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one; JAK Inhibitor I
Molecular Weight:
309.34
Molecular Formula:
C18H16FN3O
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Baricitinib | JAK 1/2 inhibitor

CAS:
1187594-09-7
Catalog Number:
10-3893
Activity:
JAK 1/2 inhibitor
Chemical Name:
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrile
Alternate Name:
INCB028050; LY3009104
Molecular Weight:
371.42
Molecular Formula:
C16H17N7O2S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

JNK

JNK-IN-8 | Covalent JNK inhibitor

JNK-IN-8 (1410880-22-6) is a  potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1  JNK blockade with JNK-IN-8 overcomes

JNK inhibitor IX | JNK inhibitor

CAS:
312917-14-9
Catalog Number:
10-1528
Activity:
JNK inhibitor
Chemical Name:
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide
Alternate Names:
TCS JNK 5a
Molecular Weight:
332.42
Molecular Formula:
C20H16N2OS
Solubility:
Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

IQ-1S | JNK3 inhibitor

CAS:
1421610-21-0
Catalog Number:
10-1513
Activity:
JNK3 inhibitor
Chemical Name:
11H-Indeno[1,2-b]quinoxaline-11-one oxime, sodium salt
Molecular Weight:
269.23
Molecular Formula:
C15H8N3O • Na
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Metabolic

UNC7467 | IP6K inhibitor

UNC7467 (2922283-43-8) is a potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ß cells, attenuates certain aspects

PF-543 HCl | Sphingosine kinase-1 inhibitor

PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous

CBR-470-1 | NRF2 signaling activator

CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates

mTOR

PI-103 | Potent inhibitor of PI-3 kinase, mTOR, and DNA-PK

CAS:
371935-74-9
Catalog Number:
10-5406
Activity:
Potent inhibitor of PI-3 kinase, mTOR and DNA-PK
Chemical Name:

3-[4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

Molecular Weight:
348.36
Molecular Formula:
C19H16N4O3
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC

NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Torin1 | mTOR inhibitor

CAS:
1222998-36-8
Catalog Number:
10-3013
Activity:
mTOR inhibitor
Chemical Name:
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Molecular Weight:
607.62
Molecular Formula:
C35H28F3N5O2
Solubility:
Soluble in DMSO (up to 8 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

INK-128 | TORC1/2 inhibitor

CAS:
1224844-38-5
Catalog Number:
10-3362
Activity:
TORC1/2 inhibitor
Chemical Name:
3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Alternate Names:
MLN-0128
Molecular Weight:
309.33
Molecular Formula:
C15H15N7O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Multikinase

HA-100·2HCl | Multi-kinase inhibitor

CAS:
85568-24-6
Catalog Number:
10-1609
Activity:
Multi-kinase inhibitor
Chemical Names:
5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
Molecular Weight:
350.26
Molecular Formula:
C13H15N3O2S·2HCl
Solubility:
Soluble in DMSO (30 mg/ml); water (40 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

KW-2449 | Multikinase inhibitor

CAS:
1000669-72-6
Catalog Number:
10-4448
Activity:
Multikinsae inhibitor
Chemical Names:
[4-[(E)-2-(1H-Indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone
Molecular Weight:
332.40
Molecular Formula:
C20H20N4O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>97% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

p38

VX-702 | P38alpha MAP kinase inhibitor

CAS:
745833-23-2
Catalog Number:
10-2181
Activity:
p38alpha MAP kinase inhibitor
Chemical Name:
6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Molecular Weight:
404.32
Molecular Formula:
C19H12F4N4O2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Doramapimod | p38 MAPK inhibitor

CAS:
285983-48-4
Catalog Number:
10-2128
Activity:
p38 MAPK inhibitor
Chemical Name:
1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalene-1-yl]urea
Alternate Names:
BIRB-796
Molecular Weight:
527.66
Molecular Formula:
C31H37N5O3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

SB 202190 | p38 MAP kinase inhibitor

CAS:
152121-30-7
Catalog Number:
10-2172
Activity:
p38 MAP kinase inhibitor
Chemical Name:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Molecular Weight:
331.35
Molecular Formula:
C20H14N3OF
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

pan-kinase

CZC-8004 | Multi-kinase inhibitor

CAS:
916603-07-1
Catalog Number:
10-3032
Activity:
Multi-kinase inhibitor; affinity ligand
Chemical Name:
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-[yrimidinediamine
Molecular Weight:
309.33
Molecular Formula:
C17H16FN5
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Staurosporine | Kinase inhibitor (pan-specific)

CAS:
62996-74-1
Catalog Number:
10-2104
Activity:
Kinase inhibitor (pan-specific)
Molecular Weight:
466.53
Molecular Formula:
C28H26N4O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off white to pale yellow solid
Purity:
>98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
Shipping Code:
RT

K252A | Kinase inhibitor (pan-specific)

CAS:
99533-80-9
Catalog Number:
10-2080
Activity:
Kinase inhibitor (pan-specific)
Molecular Weight:
467.49
Molecular Formula:
C27H21N3O5
Solubility:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

PI3K

Buparlisib | PI3-kinase inhibitor

CAS:
944396-07-0
Catalog Number:
10-4325
Activity:
pan-Class I PI3-kinase inhibitor
Chemical Names:
5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine; NVP-BKM120
Molecular Weight:
410.39
Molecular Formula:
C18H21F3N6O2
Solubility:
Soluble in DMSO (15 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PI-103 | Potent inhibitor of PI-3 kinase, mTOR, and DNA-PK

CAS:
371935-74-9
Catalog Number:
10-5406
Activity:
Potent inhibitor of PI-3 kinase, mTOR and DNA-PK
Chemical Name:

3-[4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

Molecular Weight:
348.36
Molecular Formula:
C19H16N4O3
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC

NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

PKC

Calphostin C | Protein kinase C inhibitor

CAS:
121263-19-2
Catalog Number:
10-5635
Activity:
Protein Kinase C inhibitor
Source:
Fermentation product from Caldisporium cladosporioides
Alternate Names:
UNC-1028C; PFK115-584
Molecular Weight:
790.77
Molecular Formula:
C44H38O14
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Dark red to light brown solid
Purity:
>95% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cercosporin | ROS-generating fungal toxin

CAS:
35082-49-6
Catalog Number:
10-3447
Activity:
ROS-generating fungal toxin
Chemical Names:
(13bR)-6,12-Dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione
Alternate Name:
NSC-153111
Molecular Weight:
534.52
Molecular Formula:
C29H26O4
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Dark red solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Intelliscreen™ Protein Kinase C Mini-Library

Catalog Number:
10-7315
Description:
5 inhibitors of the various PKC isozymes.
Solubility:
DMSO
Supplied As:
DSMO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$325.00

RAF

PLX4720 | Mutant B-Raf inhibitor

CAS:
918505-84-7
Catalog Number:
10-5113
Activity:
Mutant B-Raf inhibitor
Chemical Names:
N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Molecular Weight:
413.82
Molecular Formula:
C17H14ClF2N3O3S
Solubility:
Soluble in DMSO (30 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Locostatin | RKIP/Raf-1 kinase disruptor

CAS:
133812-16-5
Catalog Number:
10-5381
Activity:
RKIP/Raf-1 kinase disruptor
Chemical Names:
(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005
Molecular Weight:
245.28
Molecular Formula:
C14H15O3
Solubility:
Soluble in DMSO (60 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PLX-4032 | BRAF inhibitor

CAS:
918504-65-1
Catalog Number:
10-2928
Activity:
BRAF inhibitor
Chemical Name:
N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Alternate Names:
Vemurafenib, R7204, Ro 51-85426
Molecular Weight:
489.92
Molecular Formula:
C23H18ClF2N3O3S
Solubility:
Soluble in DMSO (up to 100 mg/ml)
Physical Properties:
White or off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

SRC

Bosutinib | Dual Src/Abl kinase inhibitor

CAS:
380843-75-4
Catalog Number:
10-2122
Activity:
Dual Src/Abl kinase inhibitor
Chemical Names:
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Alternate Name:
SKI-606
Molecular Weight:
530.45
Molecular Formula:
C26H29Cl2N5O3
Solubility:
Soluble in DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

WH-4-023 | Src family kinase inhibitor

CAS:
837422-57-8
Catalog Number:
10-5124
Activity:
Src family kinase inhibitor
Chemical Names:
N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid 2,6-dimethylphenyl ester
Molecular Weight:
568.67
Molecular Formula:
C32H36N6O4
Solubility:
Soluble in DMSO (60 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Shipping Code:
RT

Saracatinib | Src family kinase inhibitor

CAS:
379231-04-6
Catalog Number:
10-2901
Activity:
Src family kinase inhibitor
Chemical Names:
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine; AZD0530
Molecular Weight:
542.03
Molecular Formula:
C27H32ClN5O5
Solubility:
Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Other