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Kinases

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  • 3-Methyladenine | Autophagosome inhibitor
    $44.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

  • 6BIO | 667463-62-9 | Structure | Supplier
    $65.00
    6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells...

  • 7,8-Dihydroxyflavone | 38183-03-8 | Structure | Supplier
    $45.00
    7,8-Dihydroxyflavone (38183-03-8) is a selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2  Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the...

  • 7-Cl-O-Nec1 | RIP1 inhibitor
    $50.00
    7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of...

  • A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator
    $72.00
    A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator.  Activates AMPK by binding to the β and γ subunits and not the AMP binding site.1 EC50=0.8 mM for...

  • A83-01 | 909910-43-6 | Structure | Supplier
    $78.00
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

  • AAL-993 | 269390-77-4 | Structure | Supplier
    $110.00
    AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM...

  • Afatinib | EGFR and HER2 inhibitor
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

  • AG 1478 | EGFR kinase inhibitor
    $50.00
    AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines1,2. AG-1478 reduces pulmonary fibrosis in a rat model3. Cell...

  • AG-1296 | 146535-11-7 | Structure | supplier
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • AG-1517 HCl | 153436-54-5 | Structure | Supplier
    $70.00
    AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively...

  • AG-490 | 133550-30-8 | Structure | Supplier
    $50.00
    AG-490 (133550-30-8) is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and...

  • AG-879 | 148741-30-4 | Structure | Supplier
    $70.00
    AG-879 (148741-30-4) inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 μM). No inhibition of EGF, or PDGF receptor phosphorylation is...

  • AICAR | 2627-69-2 | Structure | Supplier
    $45.00
    AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor. Promotes skeletal muscle autophagy via activation of FoxO3a. AICAR controls smooth muscle cell...

  • Alsterpaullone | 237430-03-4 | Structure | Supplier
    $56.00
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

  • Amlexanox | 68302-57-8 | Structure | Supplier
    $40.00
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models1. Amlexanox increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1...

  • ANA-12 | TrkB antagonist
    $87.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • Apigenin | 520-36-5 | Structure | Supplier
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • AR-A 014418 | 487021-52-3 | Structure | Supplier
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

  • AS-041164 | PI3-K gamma inhibitor | Structure | Supplier
    $60.00
    AS-041164 (6318-41-8) is a potent, ATP-competitive, and isoform-selective PI3-Kinase inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 μM for the γ, α, β, and δ isoforms respectively).1 Cell permeable...

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