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JNK-IN-8 | Covalent JNK inhibitor

CAS:
 1410880-22-6
Catalog Number:
 10-4780

JNK-IN-8 (1410880-22-6) is a  potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1  JNK blockade with JNK-IN-8 overcomes PD-L1-mediated resistance to chemotherapy in colorectal cancer.2  Improves ARDS-induced cognitive impairment by inhibition of JNK/NF-kB-mediated NLRP3 inflammasome activation.3

References/Citations:

  1. Zhang et al. (2012), Discovery of potent and selective covalent inhibitors of JNK; Chem. Biol. 19 140
  2. Sun et al. (2021), Irreversible JNK blockade overcomes PD-Li-mediated resistance to chemotherapy in colorectal cancer; Oncogene 40 5105
  3. Shi et al. (2023), JNK-IN-8 treatment improves ARDS-induced cognitive impairment by inhibiting JNK/NF-kB-mediated NLRP3 inflammasome; Brain Behav. 13 e2980
JNK-IN-8 | Covalent JNK inhibitor is also available in the Cellular Metabolism Library.
CAS:
1410880-22-6
Catalog Number:
10-4780
Activity:
Potent and selective JNK inhibitor
Chemical Names:
3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
Molecular Weight:
507.60
Molecular Formula:

C29H29N7O2

Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Pale yellow solid
Purity:

>98% by HPLC
NMR: Conforms

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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