my account
Login
  Loading... Please wait...

Other

Sort by
  • 7,8-Dihydroxyflavone | 38183-03-8 | Structure | Supplier
    $45.00
    7,8-Dihydroxyflavone (38183-03-8) is a selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2  Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the...

  • 7-Cl-O-Nec1 | RIP1 inhibitor
    $50.00
    7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of...

  • A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator
    $72.00
    A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator.  Activates AMPK by binding to the β and γ subunits and not the AMP binding site.1 EC50=0.8 mM for...

  • AG-1296 | 146535-11-7 | Structure | supplier
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • Amlexanox | 68302-57-8 | Structure | Supplier
    $40.00
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models1. Amlexanox increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1...

  • ANA-12 | TrkB antagonist
    $87.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • BML-277 | 516480-79-8 | Structure | Supplier
    $90.00
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

  • BML283 | PKM2 activator
    $45.00
    BML283 (562867-96-3) is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM.1 PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and...

  • BRD-7389 | 376382-11-5 | Structure | Supplier
    $80.00
    BRD-7389 (376382-11-5) inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively.1 Induces a β-cell-like state in pancreatic α-cells and induces insulin...

  • BT2 | BCKDC kinase inhibitor
    $50.00
    BT2 (34576-94-8) is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM.1  Inhibition of this kinase has been shown to reduce levels of branched-chain...

  • C16 | 608512-97-6 | Structure | Supplier
    $60.00
    C16 (608512-97-6) inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM).1 Inhibits ER stress-induced neuronal damage.2 Reduces brain PKR activation in vivo.3  Prevents apoptosis and IL-1β production in an...

  • CID-2011756 | 638156-11-3 | Structure | Supplier
    $75.00
    CID-2011756 (638156-11-3) is a potent and selective ATP-competitive inhibitor of protein kinase D (PKD). IC50=3.2, 0.6 and 0.7 μM for PKD1, 2 and 3 respectively. Inhibits phorbol ester-induced PKD activation in LNCaP...

  • CZC-54252 | 1191911-27-9 | Structure | Supplier
    $85.00
    CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage...

  • Deguelin | Akt inhibitor
    $70.00
    Deguelin (522-17-8) inhibits Akt.1,2 Induces apoptosis in a variety of cells.2,3 Displays cancer chemopreventive activity.4 Deguelin is cell permeable and active in vivo. References/Citations1) Chun et al...

  • Dorsomorphin | 866405-64-3 | Structure | Supplier
    $78.00
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • FAK inhibitor 14 | FAK inhibitor
    $45.00
    FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397...

  • GSK-690693 HCl | 937174-76-0 | Structure | Supplier
    $110.00
    GSK-690693 (937174-76-0) is a novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50's=2, 13, 9 nM for Akt1, 2 and 3 respectively) Antitumor activity. Active in vivo. GSK-690693 induces hyperglycemia. Cell permeable...

  • GW-2580 | cFMS kinase inhibitor
    $72.00
    GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse...

  • GW-441756 | 504433-23-2 | Structure | Supplier
    $135.00
    GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM). References/Citations1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles...

  • Harmine | MAO-A and DYRK inhibitor
    $25.00
    Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50 = 8 μM).1 Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation...

Share Focus

Connect with Focus