Latrunculin B | Inhibits actin polymerization and microfilament organization
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 µg | $45.00 | ||
| 1 mg | $190.00 |
Latrunculin B (76343-94-7) inhibits actin polymerization and disrupts microfilament organization.1 Significantly more potent than cytochalasins in the disruption of microfilament mediated processes2, causes shortening and thickening of stress fibers. Active in cell culture.3,4 Effective doses for latrunculin B vary depending upon cell type but are frequently in the low micromolar range. Note: Latrunculin B is slowly inactivated by fetal bovine serum.
References/Citations:
1) Coue et al. (1987), Inhibition of actin polymerization by latrunculin; FEBS Lett., 213 316
2) Spector et al. (1989), Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton, 13 127
3) Wakatsuki et al. (2001), Effects of cytochalasin D and latrunculin B on mechanical properties of cells; J. Cell. Sci., 114 1025
4) Cha et al. (2004), The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2 but is dependent on an intact actin cytoskeleton as determined by FRAP; Prog. Clin. Biol. Res., 230 4
5) Herrera (2021), Cell cultures, transfection and treatments. protocols.io https://dx.doi.org/10.17504/
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Latrunculin B (76343-94-7) inhibits actin polymerization and disrupts microfilament organization.1 Significantly more potent than cytochalasins in the disruption of microfilament mediated processes2, causes shortening and thickening of stress fibers. Active in cell culture.3,4 Effective doses for latrunculin B vary depending upon cell type but are frequently in the low micromolar range. Note: Latrunculin B is slowly inactivated by fetal bovine serum.
References/Citations:
1) Coue et al. (1987), Inhibition of actin polymerization by latrunculin; FEBS Lett., 213 316
2) Spector et al. (1989), Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton, 13 127
3) Wakatsuki et al. (2001), Effects of cytochalasin D and latrunculin B on mechanical properties of cells; J. Cell. Sci., 114 1025
4) Cha et al. (2004), The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2 but is dependent on an intact actin cytoskeleton as determined by FRAP; Prog. Clin. Biol. Res., 230 4
5) Herrera (2021), Cell cultures, transfection and treatments. protocols.io https://dx.doi.org/10.17504/
Related products
-
Ansamitocin P3 | Microtubule depolymerizer
From $50.00CAS:66547-09-9Catalog Number:10-2199Activity:Microtubule depolymerizerMolecular Weight:635.16Molecular Formula:C32H43ClN2O9Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).Physical Properties:White solidPurity:>90% by TLC, remainder is P-1, P-2 and P-4.
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
S-Trityl-cysteine | Kinesin Eg5 inhibitor
$35.00CAS:2799-07-7Catalog Number:10-1042Activity:Kinesin Eg5 inhibitorChemical Name:(+)-S-Trityl-L-cysteineMolecular Weight:363.47Molecular Formula:C22H21NO2SSolubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:White or off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.Shipping Code:RT -
CK-666 | ARP2/3 inhibitor
From $65.00CAS:442633-00-3Catalog Number:10-3346Activity:ARP2/3 inhibitorChemical Name:2-Fluoro-N-[2-methyl-1H-indol-3-yl)ethyl]benzamideMolecular Weight:296.34Molecular Formula:C18H17FN2OSolubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml)Physical Properties:Cream-colored solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.