Lorcainide HCl | Voltage-gated sodium channel blocker
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $150.00 |
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig cardiac Na+/K+ ATPase and inhibits the enzyme (IC50 = 34 μM).3
References/Citations:
1) Sheldon et al. (1989), Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem., 35 748
2) Lynch et al. (1995), Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther., 273 554
3) Almotrefi et al. (1999), Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol., 77 866
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig cardiac Na+/K+ ATPase and inhibits the enzyme (IC50 = 34 μM).3
References/Citations:
1) Sheldon et al. (1989), Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem., 35 748
2) Lynch et al. (1995), Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther., 273 554
3) Almotrefi et al. (1999), Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol., 77 866
Related products
-
E-4031 | hERG channel blocker
From $50.00CAS:113558-89-7Catalog Number:10-1213Activity:hERG channel blockerChemical Name:N-[4-[[1-[2-(6-Methyl-3-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride dihydrateMolecular Weight:510.47Molecular Formula:C21H27N3O3S·2HCl·2H2OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.Shipping Code:RT -
Amlodipine | L-type Ca channel blocker
From $30.00CAS:88150-42-9Catalog Number:10-1210Activity:L-type Ca channel blockerMolecular Weight:408.89Molecular Formula:C20H25ClN2O5Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Dorsomorphin | AMPK inhibitor
From $60.00CAS:866405-64-3Catalog Number:10-1029Activity:AMPK inhibitorAlternate Names:Compound CChemical Name:6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidineMolecular Weight:399.49Molecular Formula:C24H25N5OSolubility:Soluble in DMSO (up to 3 mg/ml).Physical Properties:Pale yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.