my account
Login
  Loading... Please wait...

Product Details

MDL29,951 | GPR17 activator

MDL29,951 (130798-51-5) is a new, highly specific, small molecule activator of GPR171 that has been shown to be active in intact cells1. The ability to specifically activate GPR17 allows for the study of the exact role GPR17 plays in the maturation of oligodendrocytes and may lead to a therapeutic strategy to promote myelin repair. MDL29,951 is anntagonist for the strychnine-insensitive glycine binding site of the NMDA receptor (IC50 = 170 nM).2

References/Citations
1) Hennen et al. (2013), Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal., 6 ra93
2) Salituro et al. (1992) 3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem., 35 1791

swipe
Image 1

Catalog#  10-4537

$85.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
130798-51-5
Catalog Number:
10-4537
Activity:
GPR17 activator
Chemical Name:
3-(2-Carboxy-4,6-dichloroindol-3-yl)propionic acid
Molecular Weight:
302.11
Molecular Formula:
C12H9Cl2NO4
Solubility:
Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR: (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the MDL29,951 | GPR17 activator to your wish list.