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Product Details

MHY1485 | mTOR activator

MHY1485 (326914-06-1) is an mTOR activator. Suppresses autophagy by inhibiting the fusion of autophagosomes with lysosomes leading to the accumulation of enlarged autophagosomes.1 Increases ovarian follicle development.2 Displays cellular protective effects from cytotoxic doses of dexamethasone3 or UV radiation4. A useful tool for probing the cellular role of mTOR.5 Cell permeable.

References/Citations

1) Choy et al. (2012), Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion; PLoS One, 7(8) e43418
2) Cheng et al. (2015), Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators; PLoS One, 10(2) e0117769
3) Zhao et al. (2016), MHY1485 activates mTOR and protects osteoblasts from dexamethasone; Biochem. Biophys. Res. Commun., 481 212
4) Yang et al. (2017), MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling Oncotarget, Epub ahead of print.
5) Li and Siragy (2015), (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose; J. Physiol. Endocrinol. Metab., 309 E302

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Catalog#  10-1604-0005

$44.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
326914-06-1
Catalog Number:
10-1604
Activity:
mTOR activator
Chemical Name:
4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
Molecular Weight:
387.39
Molecular Formula:
C17H21N7O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in DMF (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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