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Minocycline HCl | Neuroprotective; antiapoptotic

Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of multiple sclerosis3. Displays neuroprotective activity4. Minocycline HCl may be effective in methotrexate-induced lung fibrosis5. Orally active and brain penetrant.

References/Citations
1) Padi and Kulkarni (2008), Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms; Eur. J. Pharmacol., 601 79
2) Dziembowska et al. (2013), High MMP-9 activity levels in fragile X syndrome are lowered by minocycline; Am. J. Med. Genet. A, 161A 1897
3) Brundula et al. (2002), Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis; Brain., 125 1297
4) Tikka et al. (2001), Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia; J. Neurosci., 21 2580
5) Kalemci et al. (2013), The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice; Eur. Rev. Med. Pharmacol. Sci., 17 3334

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Catalog#  10-2568

$38.00
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CAS:
13614-98-7
Catalog Number:
10-2568
Activity:
Neuroprotective; antiapoptotic
Chemical Name:
[4S-(4_,4a_,5a_,12a_)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride
Molecular Weight:
493.95
Molecular Formula:
C23H27N3O7 HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 10 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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