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Mito-Photo-DNP | Mitochondria specific, photo-activated protonophore

Mito-Photo-DNP is a mitochondria-targeted, photo-activated protonophore1. This novel tool consists of three structural units, a caged protonophore, a photocleavable linker coupled to a triphenylphosphonium moiety which confers selective uptake by the mitochondria2. Cells are treated with Mito-Photo-DNP at 200 nM and irradiated with UV light at 355 nm. Mito-Photo-DNP can be employed for selective uncoupling of either individual or a small number of mitochondria within a cell when used with fluorescence imaging1,3.  

References/Citations 

1)     Chalmers et al. (2012), Selective uncoupling of individual mitochondria within a cell using mitochondria-targeted photoactivated protonophore;  J. Am. Chem.Soc., 134 758 
2)     Smith et al. (2012), Mitochondrial pharmacology;  Trends Pharmacol. Sci., 33 341
3)     Glancy et al. (2015), Mitochondrial reticulum for cellular energy distribution in muscle; Nature, 523 617

 

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Mito-Photo-DNP | Structure | Supplier

Catalog#  10-1580-0001

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-1580
Activity:
Mitochondria specific, photo-activated protonophore
Chemical Name:
(4-(3-((2,4-Dinitrophenoxy)methyl)-4-nitrophenoxy)butyl)triphenylphosphonium
Molecular Weight:
732.51
Molecular Formula:
C35H31BrN3O8P
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 3 years as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Mito-Photo-DNP can be employed for selective uncoupling of either individual or a small number of mitochondria within a cell when used with fluorescence imaging.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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