my account
Login
  Loading... Please wait...

Product Details

Mitoguazone 2HCl | Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor

Mitoguazone (31959-87-2) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3 Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been looked at as a potential anti-cancer treatment because of it's ability to inhibit polyamine synthesis.6

References/Citations
1) Wiliams et al., (1971), Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun., 46 288
2) Corti et al., (1974), Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J., 139 351
3) Williams-Ashman and Seidenfeld, (1986), Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol., 35 1217
4) Janne and Morris, (1984), Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J., 218 947
5) Pegg et al., (1985) Induciton of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta, 842 111
6) Porter and Janne (2012) Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248

swipe
Image 1

Catalog#  10-4552

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
31959-87-2
Catalog Number:
10-4552
Activity:
Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
Alternate Names:
MGBG
Chemical Name:
Methylglyoxal bis(guanylhydrazone) dihydrochloride
Molecular Weight:
257.13
Molecular Formula:
C5H12N8 2HCl
Solubility:
Soluble in Water (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Mitoguazone 2HCl | Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor to your wish list.