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ML167 | Clk4 inhibitor

CAS:
1285702-20-6
Catalog Number:
10-4543
Activity:
Clk4 inhibitor
Chemical Name:
[5-[4-[(5-Methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanol
Molecular Weight:
335.36
Molecular Formula:
C19H17N2O3
Solubility:
Soluble in DMSO (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) – IC50 = 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM), Clk3(>10μM), Dyrk1A(>10μM), and Dyrk1B(4.4 μM).

References/Citations:

1) Rosenthal et al. (2010), An inhibitor of the Cdc2-like kinase 4 (Clk4); Probe Reports from the NIH Molecular Libraries Program

ML167 | Clk4 inhibitor is also available in the Cellular Metabolism Library.
CAS:
1285702-20-6
Catalog Number:
10-4543
Activity:
Clk4 inhibitor
Chemical Name:
[5-[4-[(5-Methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanol
Molecular Weight:
335.36
Molecular Formula:
C19H17N2O3
Solubility:
Soluble in DMSO (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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