ML210 | GPX4 inhibitor / Ferroptosis inducer
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $85.00 | ||
| 50 mg | $290.00 |
ML210 (CAS 1360705-96-9) is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
References/Citations:
1) Weiwer et al. (2012), Development of small-molecule probes that selectively kill cells induced to express mutant RAS; Bioorg. Med. Chem. Lett. 22 1822
2) Yang et al. (2014), Regulation of Ferroptotic Cancer Cell Death by GPX4; Cell 156 317
3) Viswanathan et al. (2017), Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway; Nature 547 453
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ML210 (CAS 1360705-96-9) is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
References/Citations:
1) Weiwer et al. (2012), Development of small-molecule probes that selectively kill cells induced to express mutant RAS; Bioorg. Med. Chem. Lett. 22 1822
2) Yang et al. (2014), Regulation of Ferroptotic Cancer Cell Death by GPX4; Cell 156 317
3) Viswanathan et al. (2017), Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway; Nature 547 453
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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