my account
Login
  Loading... Please wait...

Product Details

MOMIPP | Methuosis inducer

MOMIPP (1363421-46-8) is an inducer of Methuosis, a novel form of nonapoptotic cell death.1  Methuosis is characterized by fusion of macropinocytotic vesiscles into progressively larger vacuoles resulting in a decrease in metabolic activity and rupture of the cell membrane.2  MOMIPP was able to effectively reduce the growth and viability of Temozolomide-resistant glioblastoma and doxorubicin-resistant breast cancer cells at low micromolar concentrations.  MOMMIP has also been shown to disrupt vesicular trafficking at the lysosomal nexus resulting in impaired degradation of EGF and LDL receptors, defective processing of procathepsins and accumulation of autophagosomes.3

References/Citations

1) Robinson et al. (2012), Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death; J. Med. Chem. 55 1940
2) Overmeyer et al. (2008), Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis; Mol. Cancer Res. 6 965
3) Mbah et al. (2016), Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones; Cell Biol. Toxicol. Nov.7 {Epub ahead of print}

swipe
Image 1

Catalog#  10-4766-0010

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
1363421-46-8
Catalog Number:
10-4766
Activity:
Methuosis inducer
Chemical Name:
trans-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one
Molecular Weight:
292.33
Molecular Formula:
C18H16N2O2
Solubility:
Soluble in DMSO (up to 7 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Effectively reduces the growth and viability of Temozolomide-resistant glioblastoma and doxorubicin-resistant breast cancer cells at low micromolar concentrations.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the MOMIPP | Methuosis inducer to your wish list.