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N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration

CAS:
136560-78-6
Catalog Number:
10-1602
Activity:
Endogenous Uncoupler of Mitochondrial Respiration
Chemical Name:
N-Oleoyl Phe
Alternate Names:
NOPA, C18-1-Phe
Molecular Weight:
429.64
Molecular Formula:
C27H43NO3
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:

Blue Ice

N-Oleoylphenylalanine (136560-78-6) is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.1

References/Citations:

1) Long et al. (2016), The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria; Cell, 166 424

N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration is also available in the Cellular Metabolism Library.
CAS:
136560-78-6
Catalog Number:
10-1602
Activity:
Endogenous Uncoupler of Mitochondrial Respiration
Chemical Name:
N-Oleoyl Phe
Alternate Names:
NOPA, C18-1-Phe
Molecular Weight:
429.64
Molecular Formula:
C27H43NO3
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:

Blue Ice

Safety Data Sheet:

N/A

Product Data Sheet:

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