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Alzheimers

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  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

  • AR-A 014418 | 487021-52-3 | Structure | Supplier
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

  • Bexarotene | Retinoid RXR agonist
    $40.00
    Bexarotene (153559-49-0) is a highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively).1 Clinically useful antineoplastic agent for cutaneous T-cell...

  • BML-259 | 267254-00-2 | Structure | Supplier
    $60.00
    BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1 References/Citations1) Helal et al. (2004) Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as...

  • Compound 115-7c | HSP70 modulator
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

  • DAPT | gamma-secretase inhibitor
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • FPS-ZM1 | RAGE inhibitor
    $60.00
    FPS-ZM1 (945714-67-0) is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 μM). It is able to lower levels of Aβ via binding to the V domain of RAGE and can block multiple...

  • Galanthamine HBr | 1953-04-4 | Structure | Supplier
    $25.00
    Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM1. Allosteric potentiator at neuronal nicotinic ACh receptors2. Prevents β-amyloid-induced apoptosis in...

  • Indirubin-3'-monoxime | 160807-49-8 | Structure | Supplier
    $60.00
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • Mitoquinone | 444890-40-9 | Structure | Supplier
    $70.00
    Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer's disease.2 Mitoquinone protects pancreatic...

  • Monastrol | Kinesin Eg5 and mitosis inhibitor
    $80.00
    Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically...

  • Sodium Valproate | 1069-66-5 | Structure | Supplier
    $26.00
    Na Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50=400 μM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Na Valproate inhibits Aβ production and neuritic plaque formation in...

  • Nilvadipine | Syk inhibitor and Calcium channel blocker
    $70.00
    Nilvadipine (75530-68-6) is a novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro...

  • PNU 282987 | nAChR agonist
    $40.00
    PNU 282987 is a selective a7 nicotinic acetylcholine receptor (nAChR) agonist (Ki = 26 nM).1  The a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimers, Parkinsons,...

  • Rapamycin | 53123-88-9 | Structure | Supplier
    $100.00
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Rolipram | 61413-54-5 | Structure | Supplier
    $60.00
    Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and...

  • SMER-28 | Structure | Supplier
    $50.00
    Induces autophagy via an mTOR-independent pathway. Enhances clearance of b-amyloid protein in cell lines and primary neuronal culture models.1-3  May be a useful lead compound for the development of new therapeutics for...

  • Thiamet G | O-GlcNAcase alpha 1 antagonist
    $70.00
    Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and in vivo. Suppresses phosphorylation of tau...

  • Tubastatin A  HCl | HDAC inhibitor
    $29.00
    Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and...

  • Vildagliptin | DPPIV inhibitor
    $44.00
    Vildagliptin (274901-16-5) is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1).1 Delaying the degradation of GLP-1  extends the action of insulin and...

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