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Neural stem cells

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  • Clozapine-N-oxide | DREADD agonist
    Clozapine-N-oxide (34233-69-7) is a clozapine metabolite1 which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2...

  • Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity
    Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays...

  • ISX9 | 832115-62-5 | Structure | Supplier
    ISX9 (832115-62-5) promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory.1 Induces robust neuronal differentiation in adult neural...

  • LDN-193189 | Inhibitor of ALK2 and ALK3
    LDN-193189 HCl (1062368-62-0) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1  Only weak inhibition of ALK4, ALK5, and ALK7 is observed...

  • LM11A-31 | p75NTR ligand / Promotes neurogenesis
    A nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells.1 Promotes functional recovery in a mouse model of spinal contusion injury.2 Protects...

  • Neurodazine | Induces stem cell neuronal differentiation
    Neurodazine (937807-66-4) was able to induce neurogenesis of non-pluripotent myoblasts and cells derived from mature, human skeletal muscle (using 2 μM neurodazine). It was able to upregulate genes involved in...

  • Neuropathiazol | 880090-80-0 | Structure | Supplier
    Neuropathiazol (880090-88-0) induces neuronal differentiation of multipotent hippocampal neural progenitor cells. It is more potent and selective compared to retinoic acid (Cat.# 10-1138). Suppresses astrogliogenesis...

  • Prostratin | Promotes neuro-regeneration
    Prostratin (60857-08-1) is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrate.1,2 Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents.3...

  • SU-5402 | FGFR Phosphorylation inhibitor
    SU-5402 (215543-92-3) inhibits FGFR phosphorylation in vitro, in cell culture1, and in mouse tumor cell models2. SU-5402 can suppress ECP induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells via an FGFR3...

  • Synaptamide | 162758-94-3 |Structure | Supplier
    Synaptamide (162758-94-3) is an anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM.1...

  • TOFA | 54857-86-2 | Structure | Supplier
    TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1)1. Induces apoptosis in a variety of tumor cell lines2,3. Stimulates neurite outgrowth and neuronal differentiation in rat...

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