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PhysioProcesses

Neurodegeneration

Neurodegeneration is a progressive deterioration of neuronal structures and function that ultimately leads to cognitive disability, dementia, and/or motor defects depending on the affected area of the brain. Neurodegenerative disorders can be caused by genetic mutations, aggregation of misfolded proteins, accumulation of toxic intracellular proteins, organelle membrane damage, and mitochondrial dysfunction. Common disorders include multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

ALS

Repaglinide | Kir6 blocker

Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over

Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative

CAS:
346688-38-8
Catalog Number:
10-4003
Activity:
Sigma-1 ligand Neuroprotectant Neurorestorative
Chemical Name:
4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
Alternate Name:
ACR16
Molecular Weight:
281.41
Molecular Formula:
C15H23NO2S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Riluzole | Sodium channel blocker / Neuroprotective

CAS:
1744-22-5
Catalog Number:
10-2815
Activity:
Sodium channel blocker / Neuroprotective
Chemical Name:
2-Amino-6-(trifluoromethoxy)benzothiazole
Molecular Weight:
234.20
Molecular Formula:
C8H5F3N2OS
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Alzheimers

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

Huperzine A | Acetylcholinesterase Inhibitor

Huperzine A (102518-79-6) is a nootropic alkaloid from the club moss Huperzia serrata that reversibly inhibits acetylcholinesterase (AChE, preferentially the tetrameric form, Ki = 7 nM)1, and antagonizes NMDA receptors

Huntingtons

Repaglinide | Kir6 blocker

Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over

Laquinimod | Immunomodulator

CAS:
248281-84-7
Catalog Number:
10-4971
Activity:
Immunomodulator
Chemical Names:
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
Alternate Name:
ABR-215062
Molecular Weight:
356.81
Molecular Formula:
C19H17ClN2O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

QNZ | NFkB inhibitor / Store operated calcium entry

CAS:
545380-34-5
Catalog Number:
10-4009
Activity:
NF-kB inhibitor / Store-operated calcium entry
Chemical Name:
4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
Alternate Name:
EVP4593
Molecular Weight:
356.42
Molecular Formula:
C22H20N4O
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Multiple sclerosis

Laquinimod | Immunomodulator

CAS:
248281-84-7
Catalog Number:
10-4971
Activity:
Immunomodulator
Chemical Names:
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
Alternate Name:
ABR-215062
Molecular Weight:
356.81
Molecular Formula:
C19H17ClN2O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AX-024 | Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation

CAS:
1704801-24-0
Catalog Number:
10-4895
Activity:
Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
Chemical Name:
1-[[4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine hydrochloride
Molecular Weight:
375.86
Molecular Formula:
C21H22FNO2•HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Neuronal stem cells

Guggulsterone-(Z) | FXR antagonist

CAS:
39025-23-5
Catalog Number:
10-3816
Activity:
FXR antagonist
Chemical Name:
(Z)-Pregna-4,17(20)-diene-3,16-dione
Molecular Weight:
312.45
Molecular Formula:
C21H28O2
Solubility:
Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Neurodazine | Induces stem cell neuronal differentiation

CAS:
937807-66-4
Catalog Number:
10-4515
Activity:
Induces stem cell neuronal differentiation
Chemical Name:
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
Molecular Weight:
456.92
Molecular Formula:
C27H21ClN2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

TOFA | Acyl-CoA carboxylase inhibitor

CAS:
54857-86-2
Catalog Number:
10-1464
Activity:
Acyl-CoA carboxylase inhibitor
Alternate Names:
RMI-14514
Chemical Name:
5-(Tetradecyloxy)-2-furoic acid
Molecular Weight:
324.47
Molecular Formula:
C19H32O4
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Parkinsons

RECTAS | pre-mRNA splicing modulator

RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells

Repaglinide | Kir6 blocker

Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over

Rotenone | Mitochondrial Complex I Inhibitor

CAS:
83-79-4
Catalog Number:
10-2277
Activity:
Mitochondrial Complex I Inhibitor
Chemical Names:
(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Alternate Name:
NSC-26285; Nicouline
Molecular Weight:
394.42
Molecular Formula:
C23H22O6
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
Room Temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Other Neurodegeneration

Linopirdine dihydrochloride | Kv7 Blocker

Linopirdine (113168-57-3) increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a

GSK2606414 | PERK inhibitor

GSK2606414 (1337531-36-8) is a potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an

TTK21 | CBP/p300 histone acetyltransferase activator

CAS:
709676-56-2
Catalog Number:
10-5669
Activity:
Histone acetyltransferase CBP/p300 activator
Chemical Names:
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Molecular Weight:
357.76
Molecular Formula:
C17H15ClF3NO2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT