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Neurodegeneration

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  • 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
    $50.00
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

  • ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat...

  • Apomorphine HCl | 41372-20-7 | Structure | Supplier
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • AR-A 014418 | 487021-52-3 | Structure | Supplier
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

  • Benztropine mesylate | Induces remyelination of neurons
    $38.00
    Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and...

  • Compound 115-7C | 908074-72-6 | Structure | Supplier
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

  • CZC-54252 | 1191911-27-9 | Structure | Supplier
    $85.00
    CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage...

  • DAPT | gamma-secretase inhibitor
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Entacapone | COMT inhibitor - anti-Parkinsons
    $40.00
    Entacapone (130929-57-6) is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of...

  • Fasudil HCl | ROCK inhibitor
    $80.00
    Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic...

  • Filipin III | 480-49-9 | Structure | Supplier
    $120.00
    Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used...

  • FPS-ZM1 | RAGE receptor antagonist
    $60.00
    FPS-ZM1 (945714-67-0) is a high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (IC50 = 0.6 μM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple...

  • Galanthamine HBr | 1953-04-4 | Structure | Supplier
    $25.00
    Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM1. Allosteric potentiator at neuronal nicotinic ACh receptors2. Prevents β-amyloid-induced apoptosis in...

  • Ibotenic acid | NMDA and mGluR agonist
    $50.00
    Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms.  It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1...

  • Indirubin-3'-monoxime | 160807-49-8 | Structure | Supplier
    $60.00
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • LDN-57444 | 668467-91-2 | Structure | Supplier
    $90.00
    LDN-57444 (668467-91-2) inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. LDN-57444 causes dramatic alterations...

  • Leonurine | Neuroinflammation inhibitor
    $48.00
    Inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways.1 Inhibits the formation of advanced glycation end products.2 Ameliorates cognitive...

  • LM22A-4 | 37988-18-4 | Structure | supplier
    $120.00
    LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal...

  • MDL29,951 | GPR17 activator
    $85.00
    MDL29,951 (130798-51-5) is a new, highly specific, small molecule activator of GPR171 that has been shown to be active in intact cells1. The ability to specifically activate GPR17 allows for the study of the exact role GPR17...

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