Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts
BiochemicalTargets

Neurotransmitters

Neurotransmitters are peptides (opioids), monoamines (serotonin, dopamine), amino acids (glutamine), or other small molecules (GABA, acetylcholine, ATP, NO). They are stored and released by neurons to effect signals via binding to receptors on other neurons. These signals can be disrupted or enhanced in disease, and they can be modulated by drugs. Focus Biomolecules offers agonists, antagonists, precursors, and metabolites for neurotransmitter research.

Dopamine

6,7-ADTN HBr | Dopamine receptor agonist

6,7-ADTN HBr (13575-86-5) is a  broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine

Bupropion HCl | Monoamine transporter inhibitor

CAS:
31677-93-7
Catalog Number:
10-2462
Activity:
Monoamine transporter inhibitor
Chemical Names:
1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Molecular Weight:
276.20
Molecular Formula:
C13H18ClNO·HCl
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

9-Hydroxyrisperidone | Risperidone metabolite

CAS:
144598-75-4
Catalog Number:
10-2300
Activity:
Risperidone metabolite
Chemical Name:
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Alternate Name:
Paliperidone
Molecular Weight:
426.48
Molecular Formula:
C23H27FN4O3
Solubility:
Soluble in DMSO (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

GABA

Flumazenil | Benzodiazepine antagonist

CAS:
78755-81-4
Catalog Number:
10-1081
Activity:
Benzodiazepine antagonist
Chemical Name:

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Alternate Names:

Ro 1722;  Ro 15-1788

Molecular Weight:
303.29
Molecular Formula:
C15H14FN3O3
Solubility:
Soluble in DMSO (up to 8 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor

CAS:
145821-59-6
Catalog Number:
10-4384
Activity:
GABA transporter 1 (GAT1) inhibitor
Chemical Name:
(3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
Alternate Name:
NO-328
Molecular Weight:
412.00
Molecular Formula:
C20H25NO2S2 • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
Physical Properties:
Off-white or beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Metabolism

Safinamide | MAO-B inhibitor; Parkinson’s therapeutic

CAS:
133865-89-1
Catalog Number:
10-2924
Activity:
MAO-B inhibitor; Parkinson’s therapeutic
Chemical Name:
(S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide
Alternate Name:
FCE-26743; PNU-151774E; NW-1015
Molecular Weight:
302.34
Molecular Formula:
C17H19FN2O2
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

ZJ43 | Potent inhibitor of glutamate carboxypeptidases II and III

CAS:
723331-20-2
Catalog Number:
10-3904
Activity:
Potent inhibitor of glutamate carboxypeptidases II and III
Chemical Name:
N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
Molecular Weight:
304.30
Molecular Formula:
C12H20N2O7
Solubility:
Soluble in DMSO (up to at least mg/ml) or in Water (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

Rasagiline mesylate | MAO-B inhibitor, neuroprotective

CAS:
161735-79-1
Catalog Number:
10-2315
Activity:
MAO-B inhibitor, neuroprotective
Chemical Name:
(1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate
Alternate Names:
TVP-1012; Azilect
Molecular Weight:
267.34
Molecular Formula:
C12H13N • CH3SO3H
Solubility:
Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Norepinephrine

Tolcapone | COMT inhibitor / TTR aggregation inhibitor

CAS:
134308-13-7
Catalog Number:
10-3075
Activity:
COMT inhibitor / TTR aggregation inhibitor
Chemical Name:
(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Alternate Names:
Ro 40-7592
Molecular Weight:
273.24
Molecular Formula:
C14H11NO5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Norquetiapine 2HCl | Quetiapine metabolite

CAS:
111974-74-4
Catalog Number:
10-2588
Activity:
Quetiapine metabolite
Chemical Name:
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
Molecular Weight:
368.32
Molecular Formula:
C17H17N3S • 2HCl
Solubility:
Soluble in DMSO, Methanol, Distilled Water
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Serotonin

Serodolin | ß-Arrestin-biased 5-HT7 antagonist

CAS:
1814929-81-1
Catalog Number:
10-4086
Activity:
ß-Arrestin-biased 5-HT7 antagonist
Chemical Names:
1-(5-(4-(4-Fluorophenyl)piperazin-1-yl)pentyl)-1H-benzo[d]imidazole-2(3H)-one
Molecular Weight:
382.47
Molecular Formula:
C22H27FN4O
Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Dihydroergotamine mesylate | Vascular serotonin receptor agonist

CAS:
6190-39-2
Catalog Number:
10-3400
Activity:
Vascular serotonin receptor agonist
Chemical Names:
(5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate
Molecular Weight:
679.79
Molecular Formula:
C33H37N5O5·CH3SO3H
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

9-Hydroxyrisperidone | Risperidone metabolite

CAS:
144598-75-4
Catalog Number:
10-2300
Activity:
Risperidone metabolite
Chemical Name:
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Alternate Name:
Paliperidone
Molecular Weight:
426.48
Molecular Formula:
C23H27FN4O3
Solubility:
Soluble in DMSO (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT