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Neurovascular

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  • Argatroban | Thrombin inhibitor
    $56.00
    Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM)1. Prevents platelet-rich arterial thrombosis in a rabbit model2. Ameliorates early brain injury and improves neurological outcomes after...

  • Ebselen | Glutathione peroxidase mimic
    $28.00
    Ebselen (60940-34-3) is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent.1 Displays protective effects in reperfusion injury and stroke.2 Ebselen is an excellent...

  • GPI-16552 | 443794-40-9 | Structure | Supplier
    $60.00
    GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of...

  • HC-067047 | 883031-03-6 | Structure | Supplier
    $58.00
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH...

  • Ibudilast | Neuroinflammation inhibitor
    $40.00
    Phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48, 12 and 10 μM for PDE 1a, 2, 3, 4 and 5 respectively1). Acts as a cerebral vasodilator by selectively inducing a cGMP-independent...

  • MCI-186 | Antioxidant-nonphenolic
    $40.00
    MCI-186 (89-25-8), also known as edaravone,  is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 MCI-186 also protects against...

  • Sodium Valproate | 1069-66-5 | Structure | Supplier
    $26.00
    Na Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50=400 μM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Na Valproate inhibits Aβ production and neuritic plaque formation in...

  • Ozagrel HCl | Thromboxane synthase inhibitor
    $48.00
    Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM)1. Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM)1. Inhibits...

  • Pifithrin alpha | p53 inhibitor
    $50.00
    Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2...

  • TGN-020 | Aquaporin 4 blocker
    $75.00
    TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50 = 3.1 μM1. Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI2. TGN-020 increases regional cerebral blood flow as determined...

  • Vinpocetine | 42971-09-5 | Structure | Supplier
    $50.00
    Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective...

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