NKY-80 | Adenylate cyclase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $58.00 | ||
| 25 mg | $232.00 |
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4
References/Citations:
1) Onda et al. (2001), Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem., 276 47785
2) Pierre et al. (2009), Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov., 8 321
3) Brand et al. (2013), Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap., 347 265
4) Oritz-Capisano et al. (2007), Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension, 49 618
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4
References/Citations:
1) Onda et al. (2001), Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem., 276 47785
2) Pierre et al. (2009), Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov., 8 321
3) Brand et al. (2013), Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap., 347 265
4) Oritz-Capisano et al. (2007), Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension, 49 618
Related products
-
BC-11-38 | PDE-11 inhibitor
From $50.00CAS:686770-80-9Catalog Number:10-1408Activity:PDE-11 inhibitorChemical Name:6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)oneMolecular Weight:304.44Molecular Formula:C15H16N2OS2Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
BML-288 | PDE2 inhibitor
From $55.00CAS:851-55-3Catalog Number:10-1319Activity:PDE2 inhibitorChemical Name:6,7-Dihydro-5-methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-5H-furo[2,3-f]indole-7-carboxamideMolecular Weight:314.32Molecular Formula:C14H10N4O3SSolubility:Soluble in DMSO (up to 25 mg/ml)Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Vinpocetine | PDE1 inhibitor
From $30.00CAS:42971-09-5Catalog Number:10-1126Activity:PDE1 inhibitorChemical Name:(3α,16α)-Eburnamenine-14-carboxylic acid ethyl esterMolecular Weight:350.45Molecular Formula:C22H26N2O2Solubility:Soluble in DMSO (up to 5 mg/ml), in ethanol (up to 15 mg/ml) or in DMF (up to 3 mg/ml with warming)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, Ethanol, or DMF may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.