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NSC66811 | p53/mdm2 inhibitor

CAS:
6964-62-1
Catalog Number:
10-1334
Activity:
p53/mdm2 inhibitor
Chemical Name:
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Molecular Weight:
340.43
Molecular Formula:
C23H20N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
97% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

NSC66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

References/Citations:

1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759

NSC66811 | p53/mdm2 inhibitor is also available in the Cellular Metabolism Library.
CAS:
6964-62-1
Catalog Number:
10-1334
Activity:
p53/mdm2 inhibitor
Chemical Name:
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Molecular Weight:
340.43
Molecular Formula:
C23H20N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
97% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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