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Product Details

NSC59984 | p53 activator

NSC59984 (803647-40-7) is a p53 activator.  Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3

References/Citations

1) Zhang et al. (2015), Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53; Cancer Res., 75 3842
2) Ferraiuolo et al. (2016), Oncogenic Intra-p53 Family Member Interactions in Human Cancers; Front. Oncol., 6 77
3) Hong et al. (2014), Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities; Curr. Drug Targets, 15 80

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Catalog#  10-3148-0005

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
803647-40-7
Catalog Number:
10-3148
Activity:
P53 activator
Chemical Name:
(E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Molecular Weight:
265.27
Molecular Formula:
C12H15N3O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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