Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

NSC663284 | Cdc25 phosphatase inhibitor

CAS:
383907-43-5
Catalog Number:
10-1352
Activity:
Cdc25 phosphatase inhibitor
Chemical Name:
6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Molecular Weight:
321.77
Molecular Formula:
C15H16ClN3O3
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

NSC663284 (383907-43-5) is a potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B.1 Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation.2 Inhibits the growth of a variety of human tumor cell lines.3 NSC663284 acts via irreversible oxidation of the catalytic cysteine of CDC25.4

References/Citations:

1) Lazo et al. (2001), Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatases Cdc25; J. Med. Chem., 44 4042
2) Pu et al. (2002), Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-(2-morpholin-4-ylethylamino)-quinoline-3,8-dione; J. Biol. Chem., 277 46877
3) Han et al. (2004), NAD(P)H:quinone oxidoreductase-1-dependent and independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors; J. Pharmacol. Exp. Ther., 309 64
4) Brisson et al. (2005), Redox regulation of Cdc25B by cell-active quinolonediones; Mol. Pharmacol., 68 1810

NSC663284 | Cdc25 phosphatase inhibitor is also available in the Cellular Metabolism Library.
CAS:
383907-43-5
Catalog Number:
10-1352
Activity:
Cdc25 phosphatase inhibitor
Chemical Name:
6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Molecular Weight:
321.77
Molecular Formula:
C15H16ClN3O3
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee