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BiochemicalTargets

Nuclear receptors

Nuclear receptors are ligand-gated transcription factors that regulate various physiological processes such as reproduction, inflammation, metabolism, development, and immune function. The 48 human nuclear receptors are controlled by lipophilic signaling molecules: endocrine nuclear receptors bind various steroid hormones, thyroid hormone, or the biologically active forms of vitamins A and D and retinoic acid, adopted orphan nuclear receptors bind to various lipids, metabolic intermediates, or xenobiotics, and orphan receptors have no known endogenous ligand but still operate as transcription factors. Because of their ability to directly interact with and control DNA expression, they play a significant role in cancer, diabetes, immune disorders, and other pathologies.

AhR

Laquinimod | Immunomodulator

CAS:
248281-84-7
Catalog Number:
10-4971
Activity:
Immunomodulator
Chemical Names:
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
Alternate Name:
ABR-215062
Molecular Weight:
356.81
Molecular Formula:
C19H17ClN2O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

CH-223191 | Arylhydrocarbon receptor antagonist

CAS:
301326-22-7
Catalog Number:
10-3089
Activity:
Arylhydrocarbon receptor antagonist
Chemical Name:
1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide
Molecular Weight:
333.39
Molecular Formula:
C19H19N5O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cinnabarinic acid | Endogenous AhR ligand

CAS:
606-59-7
Catalog Number:
10-2883
Activity:
Endogenous AhR ligand
Chemical Name:
2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Alternate Names:
Cinnabaric acid
Molecular Weight:
300.22
Molecular Formula:
C14H8N2O6
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Androgen

Enzalutamide | Non-steroidal antiandrogen

CAS:
915087-33-1
Catalog Number:
10-3910
Activity:
Non-steroidal antiandrogen
Chemical Names:
4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; MDV3100
Molecular Weight:
464.44
Molecular Formula:
C21H16F4N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

CAR

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

Oltipraz | Nrf2 activator

CAS:
64224-21-1
Catalog Number:
10-2831
Activity:
Nrf2 activator
Chemical Name:
4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
Molecular Weight:
226.34
Molecular Formula:
C8H6N2S3
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

TCPOBOP | CAR agonist

CAS:
76150-91-9
Catalog Number:
10-1088
Activity:
CAR agonist
Chemical Name:
1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
Molecular Weight:
402.06
Molecular Formula:
C16H8Cl4N2O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Coactivators

SI-2 | Potent inhibitor of steroid receptor coactivator-3 (SRC-3)

CAS:
380537-35-9
Catalog Number:
10-3903
Activity:
Potent inhibitor of steroid receptor coactivator-3 (SRC-3)
Chemical Name:
1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine
Molecular Weight:
265.31
Molecular Formula:
C15H15N5
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Pale orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Cryptochrome

KL044 | Cryptochrome stabilizer

KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Per2 activity in reporter assays with 10-fold more potency

KL101 | Selective circadian clock protein CRY1 stabilizer

CAS:
396721-89-4
Catalog Number:
10-3907
Activity:
Selective circadian clock protein CRY1 stabilizer
Chemical Name:

N-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide

Molecular Weight:
377.51
Molecular Formula:
C22H23N3OS
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

TH301 | Selective circadian clock protein CRY2 stabilizer

CAS:
450338-32-6
Catalog Number:
10-3909
Activity:
Selective circadian clock protein CRY2 stabilizer
Chemical Name:

1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide

Molecular Weight:
485.98
Molecular Formula:
C24H24ClN3O4S
Solubility:
Soluble in DMSO
Physical Properties:
Waxy orange solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

ER & ERR

DY131 | Estrogen-related receptor ERRbeta and ERRgamma agonist

CAS:
95167-41-2
Catalog Number:
10-1561
Activity:
Estrogen-related receptor ERRbeta and ERRgamma agonist
Chemical Name:
N-(4-(Diethylaminobenzylidenyl)-N’-(4-hydroxybenzoyl)-hydrazine
Alternate Name:
GSK-9089
Molecular Weight:
311.38
Molecular Formula:
C18H21N3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

DPN |ERß agonist

CAS:
1428-67-7
Catalog Number:
10-2909
Activity:
Estrogen ERβ receptor agonist
Chemical Name:
2,3-bis(4-Hydroxyphenyl)-propionitrile
Alternate Names:
Diarylpropionitrile
Molecular Weight:
239.27
Molecular Formula:
C15H13NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

FXR

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

Guggulsterone-(Z) | FXR antagonist

CAS:
39025-23-5
Catalog Number:
10-3816
Activity:
FXR antagonist
Chemical Name:
(Z)-Pregna-4,17(20)-diene-3,16-dione
Molecular Weight:
312.45
Molecular Formula:
C21H28O2
Solubility:
Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Obeticholic Acid | FXR agonist

CAS:
459789-99-2
Catalog Number:
10-2838
Activity:
FXR agonist
Chemical Name:
3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid
Alternate Names:
6-Ethylchenodeoxycholic acid; 6-ECDCA
Molecular Weight:
420.63
Molecular Formula:
C26H44O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Glucocorticoid

Dexamethasone | Apoptosis inducing glucocorticoid

CAS:
50-02-2
Catalog Number:
10-1134
Activity:
Apoptosis inducing glucocorticoid
Chemical Name:
(11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Molecular Weight:
392.46
Molecular Formula:
C22H29FO5
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
RT

Mifepristone | Glucocorticoid antagonist

CAS:
84371-65-3
Catalog Number:
10-1053
Activity:
Glucocorticoid antagonist
Alternate Names:
RU486
Chemical Name:
11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Molecular Weight:
429.59
Molecular Formula:
C29H35NO2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

LXR

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

5alpha,6alpha-Epoxycholesterol | LXR ligand

CAS:
1250-95-9
Catalog Number:
10-4545
Activity:
LXR ligand
Chemical Name:
Cholestan-5α,6α-epoxy-3β-ol
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

SR9243 | LXR inverse agonist

CAS:
1613028-81-1
Catalog Number:
10-4579
Activity:
LXR inverse agonist
Chemical Name:
N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3Õ-(methylsulfonyl)[1,1Õ-biphenyl]-4-yl]methyl]-benzenesulfonamide
Molecular Weight:
626.62
Molecular Formula:
C31H32BrNO4S2
Solubility:
Soluble in DMSO (greater than 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

PPAR

Oleamide | Endogenous sleep-inducing lipid

CAS:
301-02-0
Catalog Number:
10-2923
Activity:
Endogenous sleep-inducing lipid
Chemical Names:
9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide
Molecular Weight:
281.48
Molecular Formula:
C18H35NO
Solubility:
Soluble in DMSO (25 mg/ml); Ethanol (40 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

GSK-3787 | PPARδ antagonist

CAS:
188591-46-0
Catalog Number:
10-1001
Activity:
PPARδ antagonist
Chemical Names:
4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Molecular Weight:
392.78
Molecular Formula:
C15H12ClF3N2O3S
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Formononetin | PPARgamma activator; increases adipocyte thermogenesis

CAS:
485-72-3
Catalog Number:
10-2252
Activity:
PPARγ activator; increases adipocyte thermogenesis
Chemical Name:
7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Alternate Name:
7-Hydroxy-4′-methoxyisoflavone; Biochanin B; Neochanin; NSC 93360; Formononetol
Molecular Weight:
268.26
Molecular Formula:
C16H12O4
Solubility:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Progesterone

Mifepristone | Glucocorticoid antagonist

CAS:
84371-65-3
Catalog Number:
10-1053
Activity:
Glucocorticoid antagonist
Alternate Names:
RU486
Chemical Name:
11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Molecular Weight:
429.59
Molecular Formula:
C29H35NO2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PXR

TCPOBOP | CAR agonist

CAS:
76150-91-9
Catalog Number:
10-1088
Activity:
CAR agonist
Chemical Name:
1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
Molecular Weight:
402.06
Molecular Formula:
C16H8Cl4N2O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

RAR

TTNPB | Retinoid RAR agonist

CAS:
71441-28-6
Catalog Number:
10-2517
Activity:
Retinoid RAR agonist
Chemical Names:
4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Alternate Name:
Ro 13-7410; AGN-191183
Molecular Weight:
348.49
Molecular Formula:
C24H28O3
Solubility:
Soluble in DMSO (4 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AR7 | Activates chaperone mediated autophagy

CAS:
80306-38-3
Catalog Number:
10-5515
Activity:
Activates chaperone mediated autophagy
Chemical Names:
7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
Molecular Weight:
257.72
Molecular Formula:
C15H12ClNO
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Pale pink solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

AM-580 | RARα agonist

CAS:
102121-60-8
Catalog Number:
10-5511
Activity:
RARα agonist
Chemical Names:
4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055
Molecular Weight:
351.45
Molecular Formula:
C22H25NO3
Solubility:
Soluble in DMSO (35 mg/ml) or ethanol (18 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Rev-Erb

GSK4112 | Rev-Erbα agonist

CAS:
1216744-19-2
Catalog Number:
10-5493
Activity:
Rev-Erbα agonist
Chemical Names:
N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester
Alternate Name:
SR6452
Molecular Weight:
396.89
Molecular Formula:
C18H21ClN2O4S
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

SR-8278 | REV-ERBα antagonist

CAS:
125944-66-5
Catalog Number:
10-1506
Activity:
REV-ERBα antagonist
Chemical Name:
1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Molecular Weight:
361.49
Molecular Formula:
C18H19NO3S2
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

SR-9009 | RevErb alpha/beta agonist

CAS:
1379686-30-2
Catalog Number:
10-1511
Activity:
RevErbα/β agonist
Chemical Name:
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Molecular Weight:
474.4
Molecular Formula:
C20H24CLN3O4S HCl
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

ROR

SR3335 | RORα partial inverse agonist

SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at RORß, RORγ, or FXR.1 It was able to suppress gluconeogenesis

SR1078 | ROR agonist

SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian

SR0987 |RORγt agonist

CAS:
303126-97-8
Catalog Number:
10-4008
Activity:
RORγt Agonist/Cancer immunotherapy enhancer
Chemical Name:
2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
Molecular Weight:
397.70
Molecular Formula:
C16H10F6NO2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

RXR

Methoprene Acid | Selective RXR agonist

CAS:
53092-52-7
Catalog Number:
10-4531
Activity:
Selective RXR agonist
Molecular Weight:
268.39
Molecular Formula:
C16H28O3
Solubility:
Soluble in DMSO or Ethanol
Physical Properties:
Colorless oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Bexarotene | Retinoid RXR agonist

CAS:
153559-49-0
Catalog Number:
10-2121
Activity:
Retinoid RXR agonist
Alternate Names:
LGD-1069, SR-11247
Chemical Name:
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Molecular Weight:
348.49
Molecular Formula:
C24H28O2
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Other

C-DIM 8 | Nur77 Antagonist

CAS:
151358-47-3
Catalog Number:
10-5157
Activity:
Nur77 antagonist
Chemical Names:
1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
Alternate Name:
DIM-C-pPhOH
Molecular Weight:
338.41
Molecular Formula:
C23H18N2O
Solubility:
Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
Physical Properties:
Pink solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

C-DIM 12 | Nurr1 activator; NFkB inhibitor

CAS:
178946-89-9
Catalog Number:
10-3280
Activity:
Nurr1 activator; NFkB inhibitor
Chemical Name:
3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
Molecular Weight:
356.85
Molecular Formula:
C23H17ClN2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

BI-6015 | HNF4α inhibitor

CAS:
93987-29-2
Catalog Number:
10-1402
Activity:
HNF4α inhibitor
Chemical Name:
2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Molecular Weight:
331.35
Molecular Formula:
C15H13N3O4S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT