my account
Login
  Loading... Please wait...

PPAR

Sort by
  • BADGE | PPAR gamma antagonist
    $30.00
    BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional...

  • Ciglitazone | 74772-77-3 | Structure | Supplier
    $80.00
    Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable. References/Citations1)...

  • FH-535 | 108409-83-2 | Structure | Supplier
    $50.00
    FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1...

  • GE-501516 | PPAR delta agonist
    $68.00
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • GSK-3787 | 188591-46-0 | Supplier | Structure
    $60.00
    GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) plC50 = 6.6. It covalently binds to Cys 249 in the PPARδ binding site...

  • GW-9662 | PPAR gamma antagonist
    $30.00
    GW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively)1. Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM)2...

  • LY-171883 | 88107-10-2 | Structure | Supplier
    $60.00
    LY-171883 (88107-10-2) is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 μM).1 It is also an activator of peroxisome proliferator-activated receptors (PPAR's).2,3 References/Citations1) Fleisch...

  • MK-886 | 118414-82-1 | Structure | Supplier
    $70.00
    MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10...

  • Pioglitazone | 112529-15-4 | Supplier | Structure
    $50.00
    Pioglitazone (112529-15-4) is a clinically useful antidiabetic drug.1 It is a selective agonist of the human peroxisome proliferator-activated receptor γ1(PPARγ1; EC50 = 490 nM2, 550nM3) with weak agonist...

  • Rosiglitazone maleate | 155141-29-0 | Structure | Supplier
    $40.00
    Rosiglitazone (155141-29-0) is a highly selective (KD = 40 nM)2 and potent (IC50 = 9 nM, human adipocytes)3 agonist for the peroxisome proliferator-activated receptor gamma (PPARγ). Rosiglitazone is a clinically...

  • Troglitazone | 97322-87-7 | Structure | Supplier
    $86.00
    Troglitazone (97322-87-7) is a PPARγ agonist. Stimulates recruitment of transcriptional coactivators to PPARγ at 1 μM. Stimulates adipogenesis in human mesenchymal stem cells. Troglitazone induces apoptosis in...

  • WY-14643 | 50892-23-4 | Structure | Supplier
    $60.00
    WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 µM for PPARα,γ and δ, respectively).1  Displays anti-inflammatory activity2 and reduces LPS-induced...

Share Focus

Connect with Focus