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Oleoylethanolamide | GPR119 agonist: stimulates lipolysis

CAS:
111-58-0
Catalog Number:
10-1475
Activity:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
N-(2-Hydroxyethyl)-9Z-octadecenamide
Alternate Names:
OEA
Molecular Weight:
325.53
Molecular Formula:
C20H39NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Oleoylethanolamide (111-58-0) is an endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been suggested to be its endogenous ligand4. Inhibits food intake in rodents.5 Extends the lifespan of C. elegans.6

References/Citations:

1) Lo Verme et al. (2005), Regulation of food intake by oleoylethanolamide; Cell Mol. Life Sci. 62 708
2) Magotti et al. (2015), Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids; Structure 23 598
3) Overton et al. (2006), Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecules hypophagic agents; Cell Metab. 3 167
4) Brown (2007), Novel cannabinoid receptors; Br. J. Pharmacol. 152 567
5) Nielson et al. (2004), Food intake is inhibited by oral oleoylethanolamide; J. Lipid Res. 45 1027
6) Folick et al. (2015), Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans; Science 347 83

Oleoylethanolamide | GPR119 agonist: stimulates lipolysis is also available in the Cellular Metabolism Library.
CAS:
111-58-0
Catalog Number:
10-1475
Activity:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
N-(2-Hydroxyethyl)-9Z-octadecenamide
Alternate Names:
OEA
Molecular Weight:
325.53
Molecular Formula:
C20H39NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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