my account
Login
  Loading... Please wait...

Product Details

OLT1177 | NLRP3 Inflammasome inhibitor

OLT1177 (54863-37-5) is a potent and specific inhibitor of the NLRP3 inflammasome. It significantly decreased IL-1β and IL-18 levels in LPS-stimulated human blood-derived macrophages as well as IL-1β release and caspase 1 activity in human blood neutrophils with no effect on TNFα levels. Active in vivo in both mice and humans. Oral administration to 35 healthy human subjects resulted in no adverse effects.

References/Citations

1)  Marchetti et al. (2018), OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation; Proc. Natl. Acad. Sci. USA 115 E1530

swipe
Image 1

Catalog#  10-4001-0010

$35.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
54863-37-5
Catalog Number:
10-4001
Activity:
NLRP3 Inflammasome inhibitor
Chemical Name:
3-(Methylsulfonyl)propanenitrile
Molecular Weight:
133.17
Molecular Formula:
C4H7NO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the OLT1177 | NLRP3 Inflammasome inhibitor to your wish list.