my account
Login
  Loading... Please wait...

Product Details

Oxaprozin | NFkB inhibitor

Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 μmol/l), with consequent potent analgesic activity, and NF-κB activation in inflammatory cells (IC50 = 50 μmol/l).3

References/Citations
1) Merck 14:6924
2) Ottonello et al. (2009), Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway; Br. .J. Pharmacol., 157 294
3) Dallegri et al. (2005), A review of the emerging profile of the anti-inflammatory drug oxaprozin; Expert Opin .Pharmacother., 6 777

swipe
Oxaprozin | 21256-18-8 | Structure | Supplier

Catalog#  10-1128

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
21256-18-8
Catalog Number:
10-1128
Activity:
NFκB inhibitor
Chemical Name:
4,5-Diphenyl-2-oxazolepropanoic acid
Molecular Weight:
293.32
Molecular Formula:
C18H15NO3
Solubility:
Soluble in DMSO
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Oxaprozin | NFkB inhibitor to your wish list.