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Product Details

P0180 | PRL-3 phosphatase inhibitor

P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1  Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes PRL-3-expressing cancer cells to chemotherapeutics.3 Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.4

References/Citations

1) Ahn et al. (2006), Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors; Bioorg. Med. Chem. Lett., 16 2996
2) Min et al. (2013), Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells; Bioorg. Med. Chem. Lett., 23 3769
3) Zhao et al. (2011), PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy; PLoS One, 6(5) e19798
4) Tian et al. (2012), Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783; BMC Biochemistry, 13 22

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Catalog#  10-3235-0005

$60.00
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CAS:
893449-38-2
Catalog Number:
10-3235
Activity:
PRL-3 phosphatase inhibitor
Chemical Name:
5-[[5-Bromo-2-[(2-bromophrnyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
Alternate Names:
PRL-3 inhibitor I
Molecular Weight:
485.21
Molecular Formula:
C17H11Br3NO2S2
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
FeaturedDescription:
Inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1 Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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