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Product Details

P5091 | DUB USP7 inhibitor

P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. P5091 displays antiangiogenic activity in vivo2. Cell permeable

References/Citations
1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezombi resistance; Cancer Cell, 22 345
2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789

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P5091 | 882257-11-6 | Structure | Supplier

Catalog#  10-1422

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
882257-11-6
Catalog Number:
10-1422
Activity:
DUB USP7 inhibitor
Chemical Name:
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
Molecular Weight:
348.23
Molecular Formula:
C12H7Cl2NO3S2
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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