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Ion channels

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  • 2-APB | 524-95-8 | Structure | Supplier
    $25.00
    2-APB (524-95-8) is an activator of TRPV1, V2 and V3 but not V4, V5 or V6. Has been demonstrated to potentiate the effect of capsain, protons and heat on TRPV1. 2-APB also blocks IP3 induced calcium release. Cell permeable...

  • A-803467 | 944261-79-4 | Structure | Supplier
    $67.00
    A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and...

  • A-967079 | 1170613-55-4 | Structure | Supplier
    $78.00
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in...

  • AM-404 | Anandamide transport inhibitor
    $40.00
    AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vanilloid receptors are activated by AM-404.3 Active in vivo...

  • Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

  • AP-18 | 552244-94-7 | Structure | Supplier
    $70.00
    AP-18 (55224-94-7) is a selective TRPA1 (transient receptor potential A1) channel blocker (IC50 = 3.1 and 4.5 μM at human and mouse TRPA1 respectively). References/Citations1) Petrus et al. (2007) A role of TRPA1 in...

  • BCTC | 393514-24-4 | Structure | Supplier
    $70.00
    BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally...

  • Capsaicin (natural) | TRPV1 agonist
    $80.00
    Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5. SEVERE...

  • HC-030031 | 349085-38-7 | Structure | Supplier
    $70.00
    HC-030031 (349085-38-7) inhibits TRPA1 channel. References/Citations1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104...

  • HC-067047 | 883031-03-6 | Structure | Supplier
    $58.00
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH...

  • Icilin | TRPM8 inhibitor
    $65.00
    Icilin (36945-98-9) is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2...

  • PBMC | Structure | Supplier
    $70.00
    PBMC is a potent and selective inhibitor of TRPM8 channels. PBMC inhibits both chemical and thermal activation of TRPM81. Reverses the menthol and cold-induced facilitation of the micturition reflex2. PBMC represents a new...

  • Polygodial | 6754-20-7 | Structure | Supplier
    $75.00
    Polygodial (6754-20-7) is a TRPA1 agonist (EC50=400 nM)1. A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in...

  • SB-366791 | 472981-92-3 | Structure | Supplier
    $60.00
    SB-366791 (472981-92-3) is a potent (IC50 = 0.7 µM) and selective TRPV1 antagonist.1,2 Selective for TRPV1 in a panel of 47 different binding assays. References/Citations1) Gunthorpe, et al., (2004) Identiication and...

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