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BiochemicalTargets

Phosphoinositides

Phosphoinositides are complex amphiphilic lipid-and-sugar (e.g. myo-inositol, glycerol) structures that can be found in cellular, nuclear, and organelle membranes. They can be modified, with phosphate (e.g. PIP2) or glycosyl groups, for example. They play critical roles in membrane fluidity, budding, permeability, and trafficking, as well as regulating the activity of transmembrane and membrane-associated proteins.

Phosphatidyl inositols

U-73122 | PLC inhibitor

CAS:
112648-68-7
Catalog Number:
10-1061
Activity:
PLC inhibitor
Chemical Name:
1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Molecular Weight:
464.65
Molecular Formula:
C29H40N2O3
Solubility:
Very soluble in Methylene chloride or Chloroform. Slightly soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 1 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Use caution when storing DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that turn pink should be discarded.
Shipping Code:
RT

CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase

CAS:
166981-13-1 (free base)
Catalog Number:
10-4560
Activity:
Inhibitor of CTP: choline-phosphate cytidylyltransferase
Chemical Name:
1-(11-Dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine methane sulfonate
Molecular Weight:
629.9
Molecular Formula:
C30H55N5O3 CH3SO3H
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Phosphatidylinositol (50%) | Endogenous lipid

CAS:
97281-52-2
Catalog Number:
10-2779
Activity:
Endogenous lipid
Alternate Names:
L-α-Phosphatidylinositol
Chemical Name:
1,2-Diacyl-sn-glycero-3-phosphoinositol monopotassium salt
Molecular Weight:
896.18 (linoleoyl form)
Molecular Formula:
C45H77O13PK
Solubility:
Soluble in Chloroform.
Physical Properties:
Off-white or tan solid
Purity:
50% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied.
Shipping Code:
RT

PI-3K

IPI-549 | Selective PI3Kgamma inhibitor / Immuno-oncology agent

CAS:
1693758-51-8
Catalog Number:
10-4827
Activity:
Selective PI3K-gamma inhibitor / Immuno-oncology agent
Chemical Name:
(S)-2-Amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Molecular Weight:
629.68
Molecular Formula:
C30H24N8O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

AS-605240 | PI 3-Kinase inhibitor

CAS:
348450-29-7
Catalog Number:
10-2575
Activity:
PI 3-Kinase inhibitor
Chemical Name:
5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Molecular Weight:
257.27
Molecular Formula:
C12H7N2O3
Solubility:
Soluble in DMSO (up to 1.5 mg/ml with warming)
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Idelalisib | Selective PI3Kδ Inhibitor

CAS:
870281-82-6
Catalog Number:
10-4820
Activity:
Selective PI3Kδ Inhibitor
Chemical Name:
5-Fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one
Alternate Names:
CAL-101
Molecular Weight:
415.43
Molecular Formula:
C21H18FN7O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Other

GSK2334470 | Potent and selective PDK1 inhibitor

CAS:
1227911-45-6
Catalog Number:
10-4725
Activity:
Potent and selective PDK1 inhibitor
Chemical Name:
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Molecular Weight:
462.60
Molecular Formula:
C25H34N8O
Solubility:
Soluble in DMSO (> 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT