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Phospholipases

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  • (+/-) RK-682 | Tyrosine phopshatase inhibitor
    $75.00
    RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7mu;M for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell...

  • ALLM | 136632-32-1 | Structure | Supplier
    $60.00
    ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin...

  • CTPB | 586976-24-1 | Structure | supplier
    $45.00
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

  • Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    $30.00
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

  • Flecainide acetate | Sodium channel blocker
    $50.00
    Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG...

  • HTS01037 | 682741-29-3 | Structure | Supplier
    $60.00
    HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein...

  • Lorcainide HCl | 58934-46-6 | Structure | Supplier
    $40.00
    Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig...

  • m-3M3FBS | Phospholipase C activator
    $75.00
    m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types1. Inhibits growth of U937 and THP-1 cells2. m-3M3FBS...

  • Naloxone HCl | Opioid receptor antagonist
    $50.00
    Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively1. In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3...

  • NOBA | 55894-52-5 | Structure | Supplier
    $80.00
    NOBA (55894-52-5) is a chromogenic substrate for phospholipases such as PLA2. Read absorbance at 425 nm. References/Citations1) Cho & Kezdy (1991), Chromogenic Substrates and assay of phospholipases A2; Methods Enzymol...

  • Optovin | 348575-88-2 | Structure | supplier
    $70.00
    Optovin (348575-88-2) is a reversible photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo...

  • Phosphatidylethanol | Structure | Supplier
    $78.00
    Phosphatidlyethanol is an endogenous metabolite of phosphatidylcholine. Phospholipase D converts phosphatidylcholine to phosphatidylethanol in the presence of ethanol. This reaction is the basis of a sensitive and selective...

  • Piperine | Up-regulates skeletal muscle metabolism
    $25.00
    Piperine (94-62-2) is a natural product isolated from black pepper that has myriad biological effects.  Piperine has recently been shown to increase the metabolic rate of resting muscle (fast twitch skeletal fibers)...

  • Rbin-1 | Eukaryotic ribosome assembly inhibitor
    $50.00
    Rbin-1 (328023-11-6) is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly.  The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein.  Blocking of Mdn1 by Rbin-1...

  • Safracin B | Anticancer agent
    $98.00
    Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced by Pseudomonas fluorescens.1 Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A,...

  • Salermide | SIRT1 and SIRT2 inhibitor
    $50.00
    Salermide (1105698-15-4) is a SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis...

  • SB-225002 | CXCR2 antagonist
    $60.00
    Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and...

  • SGC707 | PRMT3 inhibitor
    $65.00
    SGC707 (1687736-54-4) is a potent and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).1  IC50 = 31 nM  and selective against 31 other methyltransferases. An extremely useful probe for...

  • SHP099 | SHP2 inhibitor
    $70.00
    SHP099 (1801747-42-1) is a potent (IC50 = 71 nM) and selective allosteric inhibitor of SHP2.  SHP2 is a non-receptor tyrosine phosphatase that regulates cell survival and proliferation through activating the RAS-ERK...

  • TCEP HCl | Reducing agent
    $35.00
    TCEP HCl (51805-45-9) is a reagent for selective reduction of disulfides in aqueous solutions1-3 with distinct advantages over DTT which are application specific3. For example, spin labels are more stable with TCEP than DTT,...

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