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Protein-Protein Interaction

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  • 2-Bromopalmitic acid | Palmitoylation inhibitor
    $40.00
    2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1   References/Citations 1) Tsukamoto et al. (2013), Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells; PLoS...

  • AI-3 | 882288-28-0 | Structure | Supplier
    $75.00
    AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations...

  • CFM-4 | 331458-02-7 | Structure | Supplier
    $70.00
    CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM)1. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of...

  • Compound 115-7c | HSP70 modulator
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

  • ICG-001 | Wnt  beta-catenin inhibitor
    $65.00
    ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction References/Citations 1) Emami et al. (2004), A small molecule inhibitor of...

  • iCRT-5 | 18623-44-4 | Structure | Supplier
    $57.00
    iCRT5 (18623-44-4) is a  selective CRT (β-catenin-responsive transcription) inhibitor.1  IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1...

  • JQ1 | 1268524-69-1 | Structure | Supplier
    $65.00
    (±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding...

  • L524-0366 | Fn14 antagonist
    $65.00
    L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits...

  • NSC-23766 | Rac1 GTPase inhibitor
    $67.00
    NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely...

  • NSC-66811 | 6964-62-1 | Structure | Supplier
    $100.00
    NSC-66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable...

  • NSC59984 | p53 activator
    $50.00
    NSC59984 (803647-40-7) is a p53 activator.  Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces...

  • Nutlin-3 | 548472-68-0 | Structure | Supplier
    $100.00
    Nutlin-3 (548472-68-0) is an MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p531. Nutlin-3 displays antiproliferative activity and induces apoptosis in a variety of tumor cells...

  • PNU 74654 | Wnt pathway blocker
    $60.00
    PNU-75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50 = 450 nM) between β-catenin and T cell factor 4 (Tcf4). References/Citations1) Trosset et al. (2006) Inhibition of...

  • SL-01 | 26049-94-5 | Structure | Supplier
    $45.00
    SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ. References/Citations1) Li et al. (2011), A cell-based high-throughput assay for the screening of...

  • Stattic | STAT3 inhibitor
    $45.00
    Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation1. Displays selectivity over...

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