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  • 2-Bromopalmitic acid | Palmitoylation inhibitor
    $40.00
    2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential...

  • AI-3 | 882288-28-0 | Structure | Supplier
    $75.00
    AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations...

  • CFM-4 | 331458-02-7 | Structure | Supplier
    $70.00
    CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM)1. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of...

  • Compound 115-7C | 908074-72-6 | Structure | Supplier
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

  • JQ1 | 1268524-69-1 | Structure | Supplier
    $65.00
    (±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding...

  • L524-0366 | 951612-19-4 | Structure | Supplier
    $65.00
    L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits...

  • NSC-23766 | Rac1 GTPase inhibitor
    $67.00
    NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely...

  • PNU 74654 | Wnt pathway blocker
    $60.00
    PNU-75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50 = 450 nM) between β-catenin and T cell factor 4 (Tcf4). References/Citations1) Trosset et al. (2006) Inhibition of...

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