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Publications

Jeff Adams, President

  1. Tornquist, K., Ramstrom C., Rudnas, B., Klika, K., Dugue, B., Adams, J., Zipkin, R., Pihlaja, K., Pasternack, M. “Ceramide 1-(2-cyanoethyl)phosphate enhances store-operated Ca2+ entry in thyroid FRTL-5 cells.” Eur.J.Pharmacol. 2002, 453 1

  2. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
    Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK, Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S.
    Cancer Res. 2009 Sep 1;69(17):6915-23. doi: 10.1158/0008-5472.CAN-09-0664.

  3. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
    Paugh SW, Paugh BS, Rahmani M, Kapitonov D, Almenara JA, Kordula T, Milstien S, Adams JK, Zipkin RE, Grant S, Spiegel S.
    Blood. 2008 Aug 15;112(4):1382-91. doi: 10.1182/blood-2008-02-138958. Epub 2008 May 29.

  4. Potential anti-inflammatory actions of the elmiric (lipoamino) acids.
    Burstein SH, Adams JK, Bradshaw HB, Fraioli C, Rossetti RG, Salmonsen RA, Shaw JW, Walker JM, Zipkin RE, Zurier RB.
    Bioorg Med Chem. 2007 May 15;15(10):3345-55. Epub 2007 Mar 13.

  5. Design and synthesis of compounds that extend yeast replicative lifespan.
    Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA.
    Aging Cell. 2007 Feb;6(1):35-43. Epub 2006 Dec 5. Erratum in: Aging Cell. 2007 Aug;6(4):593. Adams, Jeffrey K [added]; Kisielewski, Anne [added]; Howitz, Konrad T [added]; Zipkin, Robert E [added].

 

 

Robert E. Zipkin, Ph.D., Scientific Advisor

  1. An Efficient and Mild Method for the Dehydrogenation of Spiroenones to Spirodienones via Organoselenium Reagents.
    R.E. Zipkin, N.R. Natale, I.M. Taffer, R.O. Hutchins. Synthesis 1035 (1980)

  2. An Expeditious and Efficient Entry into the Aphidicolin and Related Natural Products Ring Skeleton.
    K.C. Nicolaou and R.E. Zipkin, Angewandte Chemie 20, 785 (1981)

  3. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 1. Stepwise Stereocontrolled Total Synthesis of Endiandric Acids A and B.
    K.C. Nicolaou, N.A. Petasis, R.E. Zipkin and J. Uenishi. J. Am. Chem. Soc. 104, 5555 (1982)

  4. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 2. Stereocontrolled Stepwise, Stereocontrolled Total Synthesis of Endiandric Acids C-G,
    K.C. Nicolaou, N.A. Petasis. J. Uenishi, R.E. Zipkin.  J. Am. Chem. Soc. 104, 5557 (1982)

  5. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 3. Stereocontrolled “Biomimetic” Approach to Endiandric Acids A-G. Synthesis of Precursors. 
    K.C. Nicolaou, R.E. Zipkin, N.A. Petasis. J. Am. Chem. Soc. 104, 5558 (1982)

  6. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 4. “Biomimetic” Approach to Endiandric Acids A-G. Total Synthesis and Thermal Studies.
    K.C. Nicolaou, N.A. Petasis, R.E. Zipkin. J. Am. Chem. Soc. 104, 5560 (1982)

  7. Synthesis of Fecapentaene-12. K.C. Nicolaou, R.E. Zipkin, D. Tanner. J. Chem. Soc., Chem. Commun.  349 (1984)

  8. A General and Stereocontrolled Total Synthesis of Leukotriene B4 and Analogues.
    K.C. Nicolaou, R.E. Zipkin R.E. Dolle, B. Harris. J. Am. Chem. Soc. 106, 3748 (1984)

  9. An Efficient Approach to Spirosesquiterpenes. Synthesis of beta-Vetivone.
    R.O. Hutchins, R.E. Zipkin, N.R. Natale, I.M. Taffer. Syn. Commun. 14,  445 (1984)

  10. Studies of Zoapatle I. The Extraction of Zoapatle (Montanoa Tomentosa) and the identification of 21-Normontanol as the decomposition Product of Zoapatanol.
    G.B.Marcelle, N. Bunyapraphatsara, G.A. Cordell, H.H.S. Fong, K.C. Nicolaou, R.E. Zipkin J. Nat. Prod. 48, 739 (1985)

  11. Modern Synthetic Technology and Total Synthesis of Bioactive Molecules.
    K.C. Nicolaou, N.A. Petasis,  R.E. Dolle, W.S. Li, D.P. Papahatjis, J. Uenishi, R.E. Zipkin.  In New Methods in Drug Research, A. Makriyannis, Ed. J.R. Prous Publishers. pp. 179-199 (1985)

  12. A General Strategy for the Synthesis of Monohydroxyeicosatetraenoic acids: Total Synthesis of 5(S)Hydroxy-6(E),8,11,14(Z)-eicosatetraenoic acid (5-HETE) and 12(S)Hydroxy-5,8,14,(Z),10(E)-eicosatetraenoic acid (12-HETE).
    K. C. Nicolaou, T. Ladduwahetty, I.M. Taffer, R.E. Zipkin Synthesis 344 (1986)

  13. Total Synthesis of 20-Hydroxy- and 20-Carboxy- Leukotrienes B4.
    K.C. Nicolaou, Y.S Chung, P.E. Hernandez, I.M. Taffer, R.E. Zipkin Tetrahedron Lett. 27, 1881 (1986)

  14. Constriction of Cat Coronary Arteries by Synthetic Thromboxane A2 and its Antagonism.
    J.B. Smith, A. Yanagisawa, R.E. Zipkin, A.M. Lefer. Prostaglandins  33, 777 (1987)

  15. Total Enantiospecific Synthesis of 12(R)-HETE.
    I.M. Taffer, R.E. Zipkin, Tetrahedron Lett. 28, 6543 (1987)

  16. Metabolism of Cyclooxygenase and Lipoxygenase Products by 15-Hydroxyprostaglandin dehydrogenase from Human HL-60 Leukemia Cells.
    A. P. Agins, R.E. Zipkin, I.M. Taffer Inflammation Research 21, 397 (1987)

  17. Coronary Vascular Actions of Two Linoleic Acid Metabolites.
    J.-Z. Sun, R.E. Zipkin, A.M. Lefer. Med. Sci. Res. 15, 1449 (1987)

  18. Enzymatic Formation of 5,6-Dihydroxy-7,9,11,14-eicosatetraenoic acid: Kinetics of the Reaction and Stereochemistry of the Product.
    J. Haeggstrom, A. Wetterholm, M. Hamburg, J. Meijer, R.E. Zipkin, O. Radmark.  Biochim. Biophys. Acta 958, 469 (1988)

  19. Development and Application of a Membrane Receptor Assay for Leukotriene B4
    D.M. Patelunas, A.P. Agins, R.E. Zipkin, J.B. Smith Inflammation Research 27, 1023 (1989)

  20. Preparation of Omega Trideuterated Sulfidopeptide Leukotrienes: Analysis by FAB/MS.
    C. Prakash, B.J. Sweetman, R. Sivakumar, I.M. Taffer, R.E. Zipkin, I. A. Blair Prostaglandins 37, 251 (1989)

  21. Formation and Action of 8-Hydroxy -11,12-epoxy-5,9,14-eicosatrienoic acid  in Aplysia: A possible second messenger in Neurons.
    D. Piomelli, E. Shapiro, R.E. Zipkin, J.H. Schwartz, S.J. Feinmark Proc. Natl. Acad. Sci. USA 86, 1721 (1989)

  22. Selective Reductions of Conjugated Acetylenes with Magnesium in Methanol and Methanol-D.
    R.O. Hutchins, U. Suchismita, R. Sivakumar, R.E. Zipkin, I.M. Taffer, A. Monaghan, E.M. Elisseou.Tetrahedron Lett. 30, 55 (1989)

  23. Reductions of Alkyl and Aryl Halides with Magnesium and Methanol.
    R.O. Hutchins, U. Suchismita, R.E. Zipkin, I.M. Taffer, E.M. Elisseou. Syn. Commun. 19, 1519 (1989)

  24. Rabbit and Human Liver Contain a Novel Pentacyclic Triterpene Ester with Acyl-CoA:Cholesterol Acyltransferase Inhibitory Activity.
    I. Tabas, L.-L.Chen. J.W. Clader, A.T. McPhail, D.A. Burnett, P. Bartner, P.R. Das, B.N. Pramanik, M.S. Puar, S.J. Feinmark, R.E. Zipkin, G. Boykow, G. Vita, A.R. Tall. J. Biol. Chem.  265, 8042 (1990)

  25. Direct Cardiovascular Actions of Two Metabolites of Linoleic acid. 
    M.R. Siegfried N. Aoki, A.M. Lefer, E.M. Elissiou, R.E. Zipkin. Life Sci. 46, 427 (1990)

  26. Desensitization of the Leukotriene B4 Receptor by Partial Agonists.
    D. Kiel, R.E. Zipkin, S.J. Feinmark. Adv. Prostaglandin Thromboxane Leukot  21A, 403 (1991)

  27. S-Nitroso-N-Acetylpenicillamine is a Potent Inhibitor of Neutrophil-endothelial Interaction.
    X.L. Ma, A.M. Lefer, R. E. Zipkin. Endothelium 1, 31 (1993)

  28. Structural and Stereochemical Studies of Potent Inhibitors of Glucosylceramide Synthase and Tumor Cell Growth.
    A. Abe, N.S. Radin, J. Shayman, L.L. Wotring, R.E. Zipkin, R. Sivakumar, J.M. Ruggieri, K.G. Carson, B. Ganem. J. Lipid Res. 36, 611 (1995)

  29. Identification of a New Class of Molecules. The Arachidonyl Amino Acids, and Characterization of One Member that Inhibits Pain.
    S.M. Huang, T. Bisogno, T.J. Petros, S.Y. Chang, P.A. Zavitsanos, R.E. Zipkin, R. Sivakumar, A. Coop, D.Y. Maeda,  L. De Petrocellis, S. Burstein, V. Di Marzo, J.M. Walker.J. Biol. Chem. 276, 42639 (2001)

  30. Ceramide 1-(2-cyanoethyl)phosphate Enhances Store-Operated Ca2+ Entry in Thyroid FRTL-5 Cells.
    K. Tornquist, C. Ramstrom, B. Rudnas, K.D. Klika, B. Duque, J. Adams, R.E. Zipkin, K. Pihlaja, M. Pasternack  Eur. J. Pharmacol. 453, 1 (2002)

  31. N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia. 
    C.J. Chu, S.M. Huang, L. De Petrocellis, T. Bisogno, S.A. Ewing, J.D. Miller, R.E. Zipkin, N. Daddario, G. Appendino, V. Di Marzo, J.M. Walker.  J. Biol. Chem. 278,13633 (2003)

  32. Small Molecule Activators of Sirtuins Extend Saccharomyces cerevisiae  Lifespan.
    K.T. Howitz, K.J. Bitterman, H.Y. Cohen, D.W. Lamming, S. Lavu, J.G. Wood, R.E. Zipkin, P. Chung, A. Kisielewski, L.-L. Zhang, B. Scherer, D. A. Sinclair. Nature 425, 191 (2003) 

  33. Potential Anti-inflammatory actions of the Elmiric (Lipoamino) acids.
    S.H. Burstein, J.K. Adams, H.B. Bradshaw, C. Fraioli, R.G. Rossetti, R.A. Salmonsen, J.W. Shaw, J.M. Walker, R.E. Zipkin, R.B. Zurier  Bioorg. Med. Chem. 15 3345-55 (2007)

  34. Design and Synthesis of Compounds that Extend Yeast Replicative Lifespan.
    H. Yang, J.A. Baur, A. Chen, C. Miller, J.K. Adams, A. Kisielewski, K.T. Howitz, R.E. Zipkin, D.A Sinclair Aging Cell 6 35-43 (2007) and Erratum, 6 593 (2007)

  35. A Selective Sphingosine Kinase 1 Inhibitor Integrates Multiple Molecular Therapeutic Targets in Human Leukemia.
    S.W. Paugh, B.S. Paugh, M. Rahmani, D. Kapitonov, J.A. Almanara, T. Kordula, S. Milstien, J.K. Adams, R.E. Zipkin, S. Grant, S. Spiegel Blood 112 1382-91 (2008)

  36. Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis and Suppresses Growth of Human Glioblastoma Cells and Xenografts.
    D. Kapitonov, J.C. Allegood, C. Mitchell, N.C. Hait, J.A. Almanara, J.K. Adams, R.E. Zipkin, P. Dent,  T. Kordula, S. Milstien, S. Spiegel Cancer Res. 69 6915-23 (2009)

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