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Rapamycin | mTOR inhibitor

CAS:
53123-88-9
Catalog Number:
10-1104
Activity:
mTOR inhibitor
Alternate Names:
Sirolimus
Molecular Weight:
914.17
Molecular Formula:
C51H79NO13
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years  from date of purchase as supplied.  Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that binds to mTOR Complex1(mTORC1) inhibiting the mammalian target of rapamycin (mTOR).2 Rapamycin also binds to mTORC2 leading to decreased glucose tolerance and insensitivity to insulin.3 Induces autophagy.4

References/Citations:

1) Kay et al. (1991) Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology, 72 544
2) Mita et al., (2003) The molecular target of rapamycin (mTOR) as a therapeutic target against cancer; Cancer Biol. Ther., 2(4 Suppl 1) S169
3) Lamming et al. ( 2012). Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity; Science, 335 1638
4) Sarkar et al. (2009), Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies; Cell Death and Differ., 16 46

Rapamycin | mTOR inhibitor is also available in the Cellular Metabolism Library.
CAS:
53123-88-9
Catalog Number:
10-1104
Activity:
mTOR inhibitor
Alternate Names:
Sirolimus
Molecular Weight:
914.17
Molecular Formula:
C51H79NO13
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years  from date of purchase as supplied.  Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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