RIPA-56 | RIP1 kinase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $55.00 | ||
| 50 mg | $170.00 |
RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2
References/Citations:
1) Ren et al. (2017), Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem. 60 972
2) Zhang et al. (2019), RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation; Proc.Natl.Acad.Sci.USA 116 5675
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2
References/Citations:
1) Ren et al. (2017), Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem. 60 972
2) Zhang et al. (2019), RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation; Proc.Natl.Acad.Sci.USA 116 5675
Related products
-
AG-1296 | PDGFR kinase inhibitor
From $60.00CAS:146535-11-7Catalog Number:10-1087Activity:PDGFR kinase inhibitorChemical Name:6,7-Dimethoxy-3-phenylquinoxalineMolecular Weight:266.3Molecular Formula:C16H14N2O2Solubility:Soluble in DMSO.Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
ZM-336372 | c-Raf inhibitor
From $60.00CAS:208260-29-1Catalog Number:10-1030Activity:c-Raf inhibitorChemical Name:3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamideMolecular Weight:389.46Molecular Formula:C23H23N3O3Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
BML-259 | CDK5/p25 inhibitor
From $60.00CAS:267654-00-2Catalog Number:10-1025Activity:CDK5/p25 inhibitorChemical Name:N-(5-isopropyl-thiazol-2-yl)phenylacetamideMolecular Weight:260.36Molecular Formula:C14H16N2OSSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:white solidPurity:98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.