my account
Login
  Loading... Please wait...

Product Details

Rofecoxib | Selective COX-2 inhibitor

Rofecoxib (162011-90-7) is a potent and selective COX-2 inhibitor with 1000-fold selectivity over COX-1, IC50=26 nm vs >50 μM1. Potent nonsteroidal anti-inflammatory agent1. Rofecoxib is a clinically useful NSAID which was withdrawn from use due to cardiovascular side effects3.

References/Citations
1) Chan et al. (1999), Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles; J. Pharmacol. Exp. Ther., 290 551
2) Catalla-Lawson et al. (2013), Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamnics and vasoactive eicosanoids; J. Pharmacol. Exp. Ther., 289 735

swipe
Image 1

Catalog#  10-2440

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
162011-90-7
Catalog Number:
10-2440
Activity:
Selective COX-2 inhibitor
Alternate Names:
MK-966
Chemical Name:
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Molecular Weight:
314.36
Molecular Formula:
C17H14O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Rofecoxib | Selective COX-2 inhibitor to your wish list.