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BiochemicalTargets

ROS

Reactive oxygen species (ROS) are free radicals of oxygen generated in the cell by normal (e.g. mitochondrial oxidative metabolism) and abnormal (inflammation) processes. ROS homeostasis is a normal part of the redox (reduction/oxidation) mechanism, but excess ROS can react readily with, and damage, other molecules. Imbalance of ROS homeostasis leads to oxidative stress, DNA mutation, and apoptosis, and is involved in disease states such as cancer, inflammation, and aging.

Antioxidants

Lipoic acid | Endogenous antioxidant and cofactor

alpha-Lipoic acid (1077-28-7) is an endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic

Visomitin | Mitochondria-targeted antioxidant

Visomitin (934826-68-3) is a mitochondria-targeted antioxidant.1,2 A useful tool for studying mitochondrial oxidative stress involvement in many disease states.3-6 In clinical trials for the treatment of various eye

Glutathione homeostasis

2-AAPA | Glutathione/thioredoxin reductase inhibitor

CAS:
1133387-90-2
Catalog Number:
10-3238
Activity:
Glutathione/thioredoxin reductase inhibitor
Chemical Names:
R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate
Molecular Weight:
518.65
Molecular Formula:
C18H22N4O6S4
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White to off-white solid
Purity:
95% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
Shipping Code:
RT

L-Buthionine Sulfoximine | GCL inhibitor

CAS:
83730-53-4
Catalog Number:
10-4572
Activity:
GCL inhibitor
Chemical Name:
2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Molecular Weight:
222.31
Molecular Formula:
C8H18N2O3S
Solubility:
Soluble in Water (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
Shipping Code:
RT

PRIMA-1(MET) | Reactivates mutant p53

CAS:
5291-32-7
Catalog Number:
10-4175
Activity:
Reactivates mutant p53
Chemical Name:
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Alternate Names:
APR-246
Molecular Weight:
199.25
Molecular Formula:
C10H17NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
95%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Glutathione oxidase

RSL3 | GPX4 inhibitor/Ferroptosis inducer

CAS:
1219810-16-8
Catalog Number:
10-3417
Activity:
GPX4 inhibitor/Ferroptosis inducer
Chemical Names:
(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Alternate Name:
1S,3R-RSL3
Molecular Weight:
440.88
Molecular Formula:
C23H21ClN2O5
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Ebselen | Glutathione peroxidase mimic

CAS:
60940-34-3
Catalog Number:
10-2288
Activity:
Glutathione peroxidase mimic
Alternate Names:
PZ-51
Chemical Name:
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Molecular Weight:
274.18
Molecular Formula:
C13H9NOSe
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Light yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Inducers and pro-oxidants

Cercosporin | ROS-generating fungal toxin

CAS:
35082-49-6
Catalog Number:
10-3447
Activity:
ROS-generating fungal toxin
Chemical Names:
(13bR)-6,12-Dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione
Alternate Name:
NSC-153111
Molecular Weight:
534.52
Molecular Formula:
C29H26O4
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Dark red solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Hydroxyurea | Anticancer agent

CAS:
127-07-1
Catalog Number:
10-3510
Activity:
Anticancer agent
Chemical Names:
N-Hydroxyurea; Hydroxycarbamide
Molecular Weight:
76.06
Molecular Formula:
CH4N2O2
Solubility:
Soluble in water (50 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied from date of purchase. Solutions in water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

TASIN-1 | Induces Apoptosis in cells with APC truncations

CAS:
1678515-13-3
Catalog Number:
10-4890
Activity:
Induces apoptosis in cells with APC truncations
Chemical Names:
1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride
Molecular Weight:
388.95
Molecular Formula:
C18H28N2O3S·HCl
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Metal chelators

Nocardamine | Iron chelator/Ferroptosis inhibitor

CAS:
26605-16-3
Catalog Number:
10-2775
Activity:
Iron chelator/Ferroptosis inhibitor
Chemical Names:
1,12,23-Trihydroxy-1,6,12,17,23,28-hexazacyclotritriacontane-2,5,13,16,24,27-hexone
Alternate Name:
Desferrioxamine E
Molecular Weight:
600.71
Molecular Formula:
C27H48N6O9
Solubility:
Soluble in DMSO (5 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Deferasirox | Iron Chelator

CAS:
201530-41-8
Catalog Number:
10-4949
Activity:
Iron chelator
Chemical Names:
4-[3,5-bis(2-Hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
Alternate Name:
ICL670
Molecular Weight:
373.36
Molecular Formula:
C21H15N3O4
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white to white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Deferiprone | Iron Chelator

CAS:
30652-11-0
Catalog Number:
10-4950
Activity:
Iron chelator
Chemical Name:
3-Hydroxy-1,2-dimethylpyrid-4-one
Alternate Name:
Ferriprox
Molecular Weight:
139.15
Molecular Formula:
C7H9NO2
Solubility:
Soluble in Water (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
Shipping Code:
RT

Oxidative damage

Ochratoxin A | Mycotoxin

Ochratoxin A (303-47-9) is a mycotoxin that causes widespread contamination in foodstuffs and environments thus causing health risks to humans and animals.1 It has been shown to

AZD5904 | Myeloperoxidase inhibitor

CAS:
618913-30-7
Catalog Number:
10-4058
Activity:
Myeloperoxidase inhibitor
Chemical Names:
3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one
Alternate Name:
TX4
Molecular Weight:
252.29
Molecular Formula:
C10H12N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

SOD

TEMPOL | SOD mimetic

CAS:
2226-96-2
Catalog Number:
10-2471
Activity:
SOD mimetic
Chemical Names:
4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl; 4-HydroxyTEMPO
Molecular Weight:
172.24
Molecular Formula:
C9H18NO2
Solubility:
Soluble in DMSO (25 mg/ml) or Ethanol (17 mg/mL)
Physical Properties:
Orange solid
Purity:
98% GC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

MnTBAP | SOD mimetic

CAS:
55266-18-7
Catalog Number:
10-1386
Activity:
SOD mimetic
Chemical Name:
Mn(III) meso-Tetra(4-carboxyphenyl)porphine chloride
Molecular Weight:
879.17
Molecular Formula:
C48H28MnN4O8 Cl
Solubility:
Soluble in 0.1M NaOH
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.
Shipping Code:
RT

Spin traps

MGD·Na | Nitric oxide spin-trap reagent

CAS:
91840-27-6
Catalog Number:
10-4440
Activity:
Nitric oxide spin trap
Chemical Names:
N-(Dithiocarboxy)-N-methyl-D-glucamine sodium salt hydrate
Molecular Weight:
311.35 (anhydrous)
Molecular Formula:
C8H18NO6S2·Na·H2O
Solubility:
Soluble in DMSO (up to 25 mg/ml); ethanol (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

DIPPMPO | Spin Trap

CAS:
527704-58-1
Catalog Number:
10-4574
Activity:
Spin trap
Chemical Name:
5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
Molecular Weight:
263.27
Molecular Formula:
C11H22NO4P
Solubility:
Soluble in Water (up to 25 mg/ml)
Physical Properties:
Off-white to pale yellow low melting point solid.
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. Product is extremely hygroscopic, protect solid from exposure to air or moisture.
Shipping Code:
Blue Ice

CYPMPO | Spin trap

CAS:
934182-09-9
Catalog Number:
10-4521
Activity:
Spin trap
Alternate Names:
RR 071
Chemical Name:
5-(2,2-dimethyl-1,3-propoxycyclophosphoryl)-5-methyl-1-pyrroline N-oxide
Molecular Weight:
247.23
Molecular Formula:
C10H18NO4P
Solubility:
Soluble in DMSO (up to 20 mg/ml), in DMF (up to 25 mg/ml) or in PBS-pH 7.2 (up to 10 mg/ml).
Physical Properties:
Solid
Purity:
>98%
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Aqueous solutions are not stable and must be used within one working day.
Shipping Code:
RT

Other

BGP-15 | Cellular protectant

CAS:
66611-37-8
Catalog Number:
10-1373
Activity:
Cellular protectant
Chemical Names:
N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
Molecular Weight:
351.28
Molecular Formula:
C14H22N4O2·2HCl
Solubility:
Soluble in Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
Shipping Code:
RT

Auraptene | Neuroprotective / Neuritogenic agent

CAS:
495-02-3
Catalog Number:
10-2593
Activity:
Neuroprotective / Neuritogenic agent
Chemical Name:
7-[[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one
Alternate Name:
7-Geranyloxycoumarin
Molecular Weight:
298.36
Molecular Formula:
C19H22O3
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT