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Product Details

SAHA | HDAC inhibitor

SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.

References/Citations
1) Vrana et al. (1999), Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun and p21CIP1, but independent of p53; Oncogene, 18 7016
2) Butler et al. (2002), The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin; Proc. Natl. Acad. Sci. USA, 99 11700
3) Tang et al. (2012), Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells, 13 567

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SAHA | 149647-78-9 | Structure | Supplier

Catalog#  10-1067

$48.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
149647-78-9
Catalog Number:
10-1067
Activity:
HDAC inhibitor
Alternate Names:
Vorinostat
Chemical Name:
Suberoylanilide-hydroxamic acid
Molecular Weight:
264.33
Molecular Formula:
C14H20N2O3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 5 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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