Salinomycin Na | Cancer stem cell inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $100.00 |
Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1 Salinomycin Na displays selective toxicity for cancer stem cells.1 Induces rapid mitochondrial hyperpolarization.2 Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3 Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4 Kills cancer stem cells by sequestering iron.5
References/Citations:
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4) Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2) 1898
5) Mai et al. (2017) Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem., 9 1025
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1 Salinomycin Na displays selective toxicity for cancer stem cells.1 Induces rapid mitochondrial hyperpolarization.2 Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3 Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4 Kills cancer stem cells by sequestering iron.5
References/Citations:
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4) Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2) 1898
5) Mai et al. (2017) Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem., 9 1025
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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