Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma1. Salinomycin Na displays selective toxicity for cancer stem cells1. Induces rapid mitochondrial hyperpolarization2. Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway3. Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4 Kills cancer stem cells by sequestering iron.5
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4) Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2) 1898
5) Mai et al. (2017) Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem., epub. ahead of print.