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Salinomycin Na | Cancer stem cell inhibitor

Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma1. Salinomycin Na displays selective toxicity for cancer stem cells1. Induces rapid mitochondrial hyperpolarization2. Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway3. Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity4.

References/Citations
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4)
Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2) 1898

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Catalog#  10-2654

$48.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
55721-31-8
Catalog Number:
10-2654
Activity:
Cancer stem cell inhibitor
Chemical Name:
from Streptomyces albus
Molecular Weight:
772.98
Molecular Formula:
C42H69O11 Na
Solubility:
Soluble in DMSO.
Physical Properties:
White solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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