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Seriniquinone | Autophagy inducer

Seriniquinone is a  new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin as determined using an immunoaffinity approach.1

References/Citations

1) Trzoss et al. (2014), Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA, 111 14687

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Seriniquinone |Structure | Supplier

Catalog#  10-1608-0001

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-1608
Activity:
Autophagy inducer
Chemical Name:
Dinaphthol[2,3-b:2’,3’-d]thiophene-5,7,12,13-tetraone
Molecular Weight:
344.34
Molecular Formula:
C20H8O4S
Solubility:
Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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