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Seriniquinone | Autophagy inducer

Catalog Number:
10-1608
CAS #:
22200-69-7
Activity:
Autophagy inducer
Chemical Name:
Dinaphthol[2,3-b:2’,3’-d]thiophene-5,7,12,13-tetraone
Molecular Weight:
344.34
Molecular Formula:
C20H8O4S
Solubility:
Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1

References/Citations:

1) Trzoss et al. (2014), Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA, 111 14687

Seriniquinone | Autophagy inducer is also available in the Cellular Metabolism Library.
Catalog Number:
10-1608
CAS #:
22200-69-7
Activity:
Autophagy inducer
Chemical Name:
Dinaphthol[2,3-b:2’,3’-d]thiophene-5,7,12,13-tetraone
Molecular Weight:
344.34
Molecular Formula:
C20H8O4S
Solubility:
Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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